Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 2/20 | 0.54 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.54 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.39 |
| ▸ | MEN1 | O00255 | 4/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | GAA | P10253 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | CASP1 | P29466 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.34 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.34 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.34 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | AURKA | O14965 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Benzene SCHEMBL7205309 | 0.87 | GABRA1 (0.47) | GABRA1GABRB2AKR1B1KMT2AMEN1 | |
| SCHEMBL9269358 | 0.85 | GABRA1 (0.55) | GABRA1GABRB2AKR1B1KMT2AMEN1 | |
| SCHEMBL7200585 | 0.80 | GABRA1 (0.42) | GABRA1GABRB2AKR1B1KMT2AMEN1 | |
| SCHEMBL5824091 | 0.79 | GABRA1 (0.58) | GABRA1GABRB2AKR1B1KMT2AMEN1 | |
| SCHEMBL5832429 | 0.79 | FOLH1 (0.47) | GABRA1GABRB2KMT2AMEN1MAPT | |
| SCHEMBL29763626 | 0.78 | GABRA1 (0.56) | GABRA1GABRB2AKR1B1KMT2AMEN1 | |
| SCHEMBL173300 | 0.78 | GABRA1 (0.56) | GABRA1GABRB2AKR1B1KMT2AMEN1 | |
| SCHEMBL31201870 | 0.78 | GABRA1 (0.47) | GABRA1GABRB2AKR1B1ALDH1A1LMNA | |
| SCHEMBL170049 | 0.78 | GABRA1 (0.47) | GABRA1GABRB2AKR1B1ALDH1A1LMNA | |
| SCHEMBL2469944 | 0.78 | GABRA1 (0.47) | GABRA1GABRB2AKR1B1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080214660-A1 | Compounds and Methods for the Inhibition of the Expression of VCAM-1 | CRABTREE ACQUISITION CO, LLC | 2008-09-04 | — | — | US | disclosed |
| US-7375252-B2 | Compounds and method for the inhibition of the expression of VCAM-1 | ATHEROGENICS, INC. (US) | 2008-05-20 | — | — | US | disclosed |
| US-7189870-B2 | Compounds and methods for the inhibition of the expression of VCAM-1 | ATHEROGENIC, INC. (US) | 2007-03-13 | — | — | US | disclosed |
| EP-1726582-A2 | Compounds and methods for the inhibition of the expression of vcam-1 | Atherogenics, Inc. (US) | 2006-11-29 | — | — | EP | disclosed |
| EP-1695959-A1 | Compouds and methods for the inhibition of the expression of VCAM-1 | Atherogenics, Inc. (US) | 2006-08-30 | — | — | EP | disclosed |
| US-20050171028-A1 | Thioketals and thioethers for inhibiting the expression of VCAM-1 | ATHEROGENICS PHARMACEUTICALS, INC. | 2005-08-04 | — | — | US | disclosed |
| US-20050090487-A1 | Compounds and methods for the inhibition of the expression of VCAM-1 | ATHEROGENICS, INC. | 2005-04-28 | — | — | US | disclosed |
| US-6852878-B2 | Thioketals and thioethers for inhibiting the expression of VCAM-1 | ATHEROGENICS, INC. (US) | 2005-02-08 | — | — | US | disclosed |
| EP-1468989-A2 | Compounds and methods for the inhibition of the expression of VCAM-1 | Atherogenics, Inc. (US) | 2004-10-20 | — | — | EP | disclosed |
| EP-1464639-A1 | Succinic acid ester of probucol for the inhibition of the expression of VCAM-1 | Atherogenics, Inc. (US) | 2004-10-06 | — | — | EP | disclosed |
| EP-1289944-A2 | THIOKETALS AND THIOETHERS FOR INHIBITING THE EXPRESSION OF VCAM-1 | Atherogenics, Inc. (US) | 2003-03-12 | — | — | EP | disclosed |
| US-20020193446-A1 | Compounds and methods for the inhibition of the expression of VCAM-1 | CRABTREE ACQUISITION CO, LLC | 2002-12-19 | — | — | US | disclosed |
| US-20020188118-A1 | Compounds and methods for the inhibition of the expression of VCAM-1 | CRABTREE ACQUISITION CO, LLC | 2002-12-12 | — | — | US | disclosed |
| US-20020177717-A1 | Compounds and methods for the inhibition of the expression of VCAM-1 | CRABTREE ACQUISITION CO, LLC | 2002-11-28 | — | — | US | disclosed |
| US-20020169215-A1 | Compounds and methods for the inhibition of the expression of VCAM-1 | CRABTREE ACQUISITION CO, LLC | 2002-11-14 | — | — | US | disclosed |
| US-20020016300-A1 | Thioketals and thioethers for inhibiting the expression of VCAM-1 | CRABTREE ACQUISITION CO, LLC | 2002-02-07 | — | — | US | disclosed |
| WO-2001070757-A2 | THIOKETALS AND THIOETHERS FOR INHIBITING THE EXPRESSION OF VCAM-1 | ATHEROGENICS, INC. (US) | 2001-09-27 | — | — | WO | disclosed |
| US-6147250-A | TREATING DISEASES MEDIATED BY VASCULAR CELL ADHESION MOLECULE-1, INCLUDING CARDIOVASCULAR AND INFLAMMATORY DISEASES; SUCCINOBUCOL | ATHEROGENICS, INC. (US) | 2000-11-14 | — | — | US | disclosed |
| EP-0994853-A2 | COMPOUNDS AND METHODS FOR THE INHIBITION OF THE EXPRESSION OF VCAM-1 | Atherogenics, Inc. (US) | 2000-04-26 | — | — | EP | disclosed |
| WO-1998051662-A2 | COMPOUNDS AND METHODS FOR THE INHIBITION OF THE EXPRESSION OF VCAM-1 | ATHEROGENICS, INC. (US) | 1998-11-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020169215-A1 | Compounds and methods for the inhibition of the expression of VCAM-1 | VCAM1, ICAM1, SELL | GABRA1 1428/4885GABRB2 1782/4885AKR1B1 1325/4885 |
| US-20050171028-A1 | Thioketals and thioethers for inhibiting the expression of VCAM-1 | VCAM1, ICAM1, KCNT1 | GABRA1 2224/4885GABRB2 3246/4885AKR1B1 308/4885 |
| US-20020193446-A1 | Compounds and methods for the inhibition of the expression of VCAM-1 | VCAM1, ICAM1, SELL | GABRA1 1428/4885GABRB2 1782/4885AKR1B1 1325/4885 |
| US-20080214660-A1 | Compounds and Methods for the Inhibition of the Expression of VCAM-1 | VCAM1, ICAM1, SELL | GABRA1 1428/4885GABRB2 1782/4885AKR1B1 1325/4885 |
| US-20020177717-A1 | Compounds and methods for the inhibition of the expression of VCAM-1 | VCAM1, ICAM1, SELL | GABRA1 1428/4885GABRB2 1782/4885AKR1B1 1325/4885 |
| US-20020016300-A1 | Thioketals and thioethers for inhibiting the expression of VCAM-1 | VCAM1, ICAM1, KCNT1 | GABRA1 2224/4885GABRB2 3246/4885AKR1B1 308/4885 |
| US-20020188118-A1 | Compounds and methods for the inhibition of the expression of VCAM-1 | VCAM1, ICAM1, SELL | GABRA1 1428/4885GABRB2 1782/4885AKR1B1 1325/4885 |
| US-20050090487-A1 | Compounds and methods for the inhibition of the expression of VCAM-1 | VCAM1, ICAM1, SELL | GABRA1 1428/4885GABRB2 1782/4885AKR1B1 1325/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.