Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.45 |
| ▸ | NOTUM | Q6P988 | 4/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | USP1 | O94782 | 1/20 | 0.43 |
| ▸ | WDR48 | Q8TAF3 | 1/20 | 0.43 |
| ▸ | CXCL12 | P48061 | 1/20 | 0.42 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.42 |
| ▸ | ACHE | P22303 | 2/20 | 0.41 |
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8811827 | 0.81 | HRH3 (0.54) | HRH3POLBHDAC1NOTUMKDM4E | |
| SCHEMBL8818072 | 0.77 | HRH3 (0.60) | HRH3POLBHDAC1KDM4EALDH1A1 | |
| SCHEMBL10953965 | 0.76 | HRH3 (0.88) | HRH3POLBHDAC1KDM4EALDH1A1 | |
| SCHEMBL9062963 | 0.75 | HRH3 (0.54) | HRH3POLBHDAC1KDM4EALDH1A1 | |
| SCHEMBL8808479 | 0.75 | HRH3 (0.54) | HRH3POLBHDAC1NOTUMKDM4E | |
| SCHEMBL8810828 | 0.75 | HRH3 (0.62) | HRH3POLBHDAC1KDM4EALDH1A1 | |
| SCHEMBL20868291 | 0.74 | NOTUM (0.58) | NOTUMUSP1WDR48PARP1 | |
| SCHEMBL21449052 | 0.74 | NOTUM (0.57) | NOTUMUSP1WDR48PARP1 | |
| SCHEMBL19650814 | 0.72 | BRD4 (0.50) | HRH3NOTUMKDM4EALDH1A1CXCR4 | |
| SCHEMBL5863541 | 0.72 | HRH3 (0.67) | HRH3POLBHDAC1KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1996010559-A1 | UREA DERIVATIVES AND THEIR USE AS ACAT-INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1996-04-11 | — | — | WO | disclosed |