Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 11/20 | 0.57 |
| ▸ | HTR2A | P28223 | 10/20 | 0.57 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 3/20 | 0.52 |
| ▸ | USP2 | O75604 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | PKM | P14618 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | GRM5 | P41594 | 1/20 | 0.51 |
| ▸ | HTR2B | P41595 | 4/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14458188 | 0.84 | NPC1 (0.67) | HTR2CHTR2ARIPK1LMNAUSP2 | |
| SCHEMBL9053646 | 0.83 | HTR2C (0.67) | HTR2CHTR2ARIPK1LMNAUSP2 | |
| SCHEMBL2481583 | 0.83 | HTR2A (0.64) | HTR2CHTR2ARIPK1LMNAUSP2 | |
| SCHEMBL9062442 | 0.83 | GAA (0.59) | HTR2CHTR2AGAASMN1; SMN2HTR2B | |
| SCHEMBL9051767 | 0.82 | ALDH1A1 (0.64) | HTR2CHTR2ALMNAPKMTSHR | |
| SCHEMBL9053122 | 0.81 | MEN1 (0.52) | HTR2CHTR2ALMNAUSP2PKM | |
| SCHEMBL9052316 | 0.81 | GRM5 (0.52) | HTR2CHTR2AUSP2PKMTSHR | |
| SCHEMBL6032387 | 0.81 | MEN1 (0.60) | HTR2CHTR2ARIPK1LMNAUSP2 | |
| SCHEMBL9052538 | 0.79 | ATM (0.64) | HTR2CLMNAGAAPKMHTT | |
| SCHEMBL9053892 | 0.79 | POLB (0.59) | LMNAUSP2PKMTSHRSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0743946-A1 | 5HT2B RECEPTOR ANTAGONISTS CONDENSED INDOLES | SMITHKLINE BEECHAM PLC (GB) | 1996-11-27 | — | — | EP | claimed |
| WO-1995021844-A1 | 5HT2B RECEPTOR ANTAGONISTS CONDENSED INDOLES | SMITHKLINE BEECHAM PLC (GB) | 1995-08-17 | — | — | WO | claimed |
| WO-1995021844-A1 | 5HT2B RECEPTOR ANTAGONISTS CONDENSED INDOLES | SMITHKLINE BEECHAM PLC (GB) | 1995-08-17 | — | — | WO | disclosed |