Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.67 |
| ▸ | RAB9A | P51151 | 5/20 | 0.67 |
| ▸ | NFKB1 | P19838 | 4/20 | 0.67 |
| ▸ | NFKB2 | Q00653 | 4/20 | 0.67 |
| ▸ | RELA | Q04206 | 4/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.67 |
| ▸ | PKM | P14618 | 3/20 | 0.67 |
| ▸ | TP53 | P04637 | 2/20 | 0.67 |
| ▸ | MAPT | P10636 | 3/20 | 0.61 |
| ▸ | HTR2C | P28335 | 3/20 | 0.61 |
| ▸ | HTR2A | P28223 | 2/20 | 0.61 |
| ▸ | LMNA | P02545 | 3/20 | 0.58 |
| ▸ | MEN1 | O00255 | 2/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.57 |
| ▸ | MAOB | P27338 | 1/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.55 |
| ▸ | ATM | Q13315 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2481583 | 0.87 | HTR2A (0.64) | NPC1RAB9ANFKB1NFKB2RELA | |
| SCHEMBL28367602 | 0.86 | NPC1 (0.72) | NPC1RAB9ANFKB1NFKB2RELA | |
| SCHEMBL9056673 | 0.84 | HTR2C (0.57) | SMN1; SMN2PKMMAPTHTR2CHTR2A | |
| SCHEMBL20016692 | 0.83 | P2RX1 (0.70) | NPC1RAB9ANFKB1NFKB2RELA | |
| SCHEMBL14477461 | 0.81 | LMNA (0.56) | NPC1RAB9ANFKB1NFKB2RELA | |
| SCHEMBL382910 | 0.81 | NPC1 (1.00) | NPC1RAB9ANFKB1NFKB2RELA | |
| SCHEMBL1574545 | 0.81 | GRIN2B (0.56) | RAB9AMAPTLMNAMEN1KMT2A | |
| SCHEMBL3175847 | 0.80 | HTR2C (0.63) | SMN1; SMN2PKMMAPTHTR2CHTR2A | |
| SCHEMBL6032387 | 0.80 | MEN1 (0.60) | SMN1; SMN2PKMTP53MAPTHTR2C | |
| SCHEMBL4554056 | 0.79 | MAPT (0.68) | NPC1RAB9ANFKB1NFKB2RELA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1815860-A2 | Phosphate transport inhibitors | GENZYME CORPORATION (US) | 2007-08-08 | — | — | EP | disclosed |
| US-20070021509-A1 | Phosphate transport inhibitors | JOZEFIAK THOMAS H | 2007-01-25 | — | — | US | disclosed |
| US-20070021509-A1 | Phosphate transport inhibitors | JOZEFIAK THOMAS H | 2007-01-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070021509-A1 | Phosphate transport inhibitors | SLC34A2, SLC34A1, SLC20A1 | NPC1 186/4885RAB9A 2409/4885NFKB1 3811/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.