Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PAM | P19021 | 1/20 | 0.53 |
| ▸ | CES1 | P23141 | 2/20 | 0.50 |
| ▸ | CES2 | O00748 | 1/20 | 0.50 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | FNTA | P49354 | 1/20 | 0.42 |
| ▸ | FNTB | P49356 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | CTBP2 | P56545 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL200592 | 0.89 | PAM (0.63) | PAMCES1CES2AKR1B1L3MBTL1 | |
| SCHEMBL23258762 | 0.78 | PAM (0.52) | PAMCES1CES2AKR1B1L3MBTL1 | |
| SCHEMBL7324963 | 0.77 | PAM (0.59) | PAMCES1CES2AKR1B1L3MBTL1 | |
| SCHEMBL15574257 | 0.76 | PAM (0.63) | PAMCES1CES2AKR1B1L3MBTL1 | |
| SCHEMBL27546894 | 0.74 | PAM (0.61) | PAMCES1CES2AKR1B1L3MBTL1 | |
| SCHEMBL3251243 | 0.73 | PAM (0.66) | PAMCES1CES2AKR1B1L3MBTL1 | |
| SCHEMBL11620196 | 0.73 | CYP2C19 (0.46) | CES1CES2AKR1B1TDP1ALDH1A1 | |
| SCHEMBL27988220 | 0.73 | PAM (0.66) | PAMCES1CES2AKR1B1L3MBTL1 | |
| Benzene SCHEMBL2333780 | 0.73 | CES1 (0.64) | PAMCES1CES2AKR1B1L3MBTL1 | |
| SCHEMBL1331954 | 0.73 | CES1 (0.64) | PAMCES1CES2AKR1B1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9169286-B2 | Use of N-alkyl imidazole for sulfurization of oligonucleotides with an acetyl disulfide | AGILENT TECHNOLOGIES, INC. (US) | 2015-10-27 | — | — | US | disclosed |
| US-8642755-B2 | Use of thioacetic acid derivatives in the sulfurization of oligonucleotides with phenylacetyl disulfide | AGILENT TECHNOLOGIES, INC. (US) | 2014-02-04 | — | — | US | disclosed |
| US-20130035261-A1 | USE OF N-ALKYL IMIDAZOLE FOR SULFURIZATION OF OLIGONUCLEOTIDES WITH AN ACETYL DISULFIDE | AGILENT TECHNOLOGIES, INC. (US) | 2013-02-07 | — | — | US | disclosed |
| US-8309710-B2 | Use of N-alkyl imidazole for sulfurization of oligonucleotides with an acetyl disulfide | AGILENT TECHNOLOGIES, INC. (US) | 2012-11-13 | — | — | US | disclosed |
| EP-2277886-B1 | The use of n-alkyl imidazole for sulfurization of oligonucleotides with an acetyl disulfide | AGILENT TECHNOLOGIES INC (US) | 2012-10-24 | — | — | EP | disclosed |
| EP-2277886-A1 | The use of n-alkyl imidazole for sulfurization of oligonucleotides with an acetyl disulfide | Agilent Technologies, Inc. (US) | 2011-01-26 | — | — | EP | disclosed |
| US-20100331532-A1 | Use Of N-Alkyl Imidazole For Sulfurization Of Oligonucleotides With An Acetyl Disulfide | AGILENT TECHNOLOGIES, INC. | 2010-12-30 | — | — | US | disclosed |
| US-20100331533-A1 | Use Of Thioacetic Acid Derivatives In The Sulfurization Of Oligonucleotides With Phenylacetyl Disulfide | AGILENT TECHNOLOGIES, INC. | 2010-12-30 | — | — | US | disclosed |