Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER1 | P34995 | 1/20 | 0.48 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.48 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.48 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.48 |
| ▸ | PLK1 | P53350 | 1/20 | 0.47 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.47 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | RARB | P10826 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | CASP6 | P55212 | 1/20 | 0.41 |
| ▸ | BID | P55957 | 1/20 | 0.41 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9057891 | 1.00 | PTGER1 (0.48) | PTGER1PTGER4PTGER3PTGER2PLK1 | |
| SCHEMBL8326737 | 0.85 | CYP4A11 (0.50) | PLK1PLK3GPR35KMT2AMEN1 | |
| SCHEMBL27864868 | 0.79 | GPR35 (0.53) | GPR35NPC1RAB9AKMT2AMEN1 | |
| SCHEMBL8405961 | 0.79 | GPR35 (0.56) | GPR35SIGMAR1NPC1RAB9AKMT2A | |
| SCHEMBL2016391 | 0.76 | GPR35 (0.56) | GPR35ALDH1A1BIDBCL2L1MCL1 | |
| SCHEMBL3555674 | 0.76 | SLC16A3 (0.60) | PLK1PLK3NPC1RAB9AKMT2A | |
| SCHEMBL27648916 | 0.75 | GPR35 (0.55) | GPR35SIGMAR1KMT2AMEN1POLB | |
| SCHEMBL8319817 | 0.74 | PTGER1 (0.61) | PTGER1PTGER4PTGER3PTGER2KMT2A | |
| SCHEMBL8402772 | 0.73 | GPR35 (0.53) | PLK1PLK3GPR35KDM4EMAPT | |
| SCHEMBL133470 | 0.72 | RARB (0.68) | PTGER1PTGER4PTGER3PTGER2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0733033-A1 | PHARMACEUTICALLY ACTIVE SUBSTITUTED AROMATIC COMPOUNDS | ZENECA LIMITED (GB) | 1996-09-25 | — | — | EP | disclosed |
| WO-1996011902-A1 | PHARMACEUTICALLY ACTIVE SUBSTITUTED AROMATIC COMPOUNDS | ZENECA LIMITED (GB) | 1996-04-25 | — | — | WO | disclosed |