Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.50 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.44 |
| ▸ | ERN1 | O75460 | 1/20 | 0.44 |
| ▸ | PLK1 | P53350 | 1/20 | 0.43 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.43 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9057899 | 0.85 | PTGER1 (0.48) | MAPTPOLBKMT2AMEN1PLK1 | |
| SCHEMBL9057891 | 0.85 | PTGER1 (0.48) | MAPTPOLBKMT2AMEN1PLK1 | |
| SCHEMBL8322742 | 0.78 | CYP4A11 (0.52) | CYP4A11CYP4F2ERN1LOXL2ALDH1A1 | |
| SCHEMBL29274264 | 0.77 | HTT (0.55) | MAPTPOLBKMT2AMEN1HTT | |
| SCHEMBL8319293 | 0.77 | CYP4A11 (0.60) | CYP4A11CYP4F2LOXL2ALDH1A1TP53 | |
| SCHEMBL4962973 | 0.77 | GPR35 (0.45) | POLBKMT2AMEN1HTTPTPN1 | |
| SCHEMBL8319038 | 0.76 | ALDH1A1 (0.58) | CYP4A11CYP4F2MAPTPOLBKMT2A | |
| SCHEMBL2016391 | 0.75 | GPR35 (0.56) | ERN1ALDH1A1CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL8411460 | 0.74 | KMT2A (0.49) | MAPTPOLBKMT2AMEN1HTT | |
| SCHEMBL8322700 | 0.74 | PTGER1 (0.56) | MAPTKMT2AMEN1ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0733033-B1 | PHARMACEUTICALLY ACTIVE SUBSTITUTED AROMATIC COMPOUNDS | ZENECA LTD (GB) | 1999-12-22 | — | — | EP | disclosed |
| US-5811459-A | PAIN RELIEVERS | ZENECA LIMITED (GB) | 1998-09-22 | — | — | US | disclosed |