SCHEMBL9058316

SCHEMBL9058316

CCCN(C(=O)C(F)(F)F)[C@H](C)Cc1ccc2ncc([N+](=O)[O-])n2n1

nearest known ligand 0.32

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 1/20 0.32
CYP2C9 P11712 1/20 0.32
MAPK1 P28482 1/20 0.31
ATM Q13315 1/20 0.31
FYN P06241 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9058711 0.77 MKNK1 (0.34) CYP1A2CYP2C9MAPK1ATM
SCHEMBL9058560 0.77 MKNK1 (0.34) CYP1A2CYP2C9MAPK1ATM
SCHEMBL9058720 0.73 MKNK1 (0.35) CYP1A2CYP2C9MAPK1ATM
SCHEMBL9058563 0.73 MKNK1 (0.35) CYP1A2CYP2C9MAPK1ATM
SCHEMBL9059217 0.72 ALDH1A1 (0.35) CYP1A2CYP2C9MAPK1ATMFYN
SCHEMBL9058561 0.71 MKNK1 (0.38) CYP1A2CYP2C9
SCHEMBL9058877 0.70 CYP1A2 (0.33) CYP1A2CYP2C9
SCHEMBL9058865 0.67 CYP1A2 (0.33) CYP1A2CYP2C9
SCHEMBL9058715 0.66 MKNK1 (0.39) CYP1A2CYP2C9MAPK1ATM
SCHEMBL9058809 0.66 MKNK1 (0.39) CYP1A2CYP2C9MAPK1ATM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-1996016656-A1 CONDENSED IMIDAZOLE DERIVATIVES, THEIR PREPARATION AND USE TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1996-06-06 WO disclosed