SCHEMBL9058728

SCHEMBL9058728

CC(=O)NCCSc1ccc2ncc([N+](=O)[O-])n2n1

nearest known ligand 0.42

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
GSTP1 P09211 1/20 0.42
GSTM2 P28161 1/20 0.42
MTNR1A P48039 4/20 0.39
MTNR1B P49286 4/20 0.39
CYP1A2 P05177 2/20 0.37
CYP2C9 P11712 1/20 0.37
GAA P10253 2/20 0.35
ALDH1A1 P00352 1/20 0.35
GLA P06280 1/20 0.35
SMN1; SMN2 Q16637 1/20 0.35
MEN1 O00255 1/20 0.34
KMT2A Q03164 1/20 0.34
RXFP1 Q9HBX9 2/20 0.33
TDP1 Q9NUW8 2/20 0.33
KDM4E B2RXH2 1/20 0.33
RAB9A P51151 1/20 0.33
FYN P06241 2/20 0.33
POLB P06746 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9058568 0.86 ALDH1A1 (0.39) CYP1A2CYP2C9ALDH1A1GLASMN1; SMN2
SCHEMBL9059134 0.83 GLA (0.37) CYP1A2CYP2C9ALDH1A1GLAMEN1
SCHEMBL9058562 0.83 ALDH1A1 (0.46) CYP1A2CYP2C9GAAALDH1A1SMN1; SMN2
SCHEMBL9058881 0.80 KDM4E (0.46) CYP1A2CYP2C9GAAALDH1A1SMN1; SMN2
SCHEMBL9058693 0.78 MAPK1 (0.43) CYP1A2CYP2C9GAAALDH1A1GLA
SCHEMBL9058877 0.77 CYP1A2 (0.33) CYP1A2CYP2C9ALDH1A1KDM4E
SCHEMBL9058875 0.76 KDM4E (0.54) CYP1A2CYP2C9GAAALDH1A1SMN1; SMN2
SCHEMBL9058576 0.76 CA1 (0.37) CYP1A2CYP2C9GLASMN1; SMN2KDM4E
SCHEMBL4492921 0.75 CYP1A2 (0.54) GSTP1GSTM2MTNR1AMTNR1BCYP1A2
Hydrochloric Acid SCHEMBL9061671 0.73 RXFP1 (0.43) GAAALDH1A1MEN1KMT2ARXFP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-1996016656-A1 CONDENSED IMIDAZOLE DERIVATIVES, THEIR PREPARATION AND USE TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1996-06-06 WO disclosed