Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D | P28221 | 13/20 | 0.45 |
| ▸ | HTR1B | P28222 | 11/20 | 0.45 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7445758 | 0.82 | HTR1D (0.62) | HTR1DHTR1BHTR1A | |
| SCHEMBL7443429 | 0.75 | HTR1D (0.53) | HTR1DHTR1BHTR1AALDH1A1 | |
| SCHEMBL7445106 | 0.62 | HTR1D (0.57) | HTR1DHTR1BHTR1A | |
| SCHEMBL8313653 | 0.62 | HTR1D (1.00) | HTR1DHTR1BHTR1A | |
| SCHEMBL7439653 | 0.61 | HTR1B (0.46) | HTR1DHTR1BHTR1A | |
| SCHEMBL3433878 | 0.60 | CYP2A6 (0.58) | HTR1DHTR1BALDH1A1CYP1A2CYP2C19 | |
| SCHEMBL2540556 | 0.60 | ALDH1A1 (0.58) | HTR1DHTR1BALDH1A1CYP1A2CYP2C19 | |
| SCHEMBL186914 | 0.59 | CYP2A6 (0.53) | ALDH1A1CYP1A2CYP2C19KDM4EMAPT | |
| SCHEMBL29956600 | 0.59 | CYP2A6 (0.53) | ALDH1A1CYP1A2CYP2C19KDM4EMAPT | |
| SCHEMBL16727124 | 0.59 | CYP2A6 (0.53) | ALDH1A1CYP1A2CYP2C19KDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0690843-A1 | INDOLETETRALINS HAVING DOPAMINERGIC ACTIVITY | PHARMACIA & UPJOHN COMPANY (US) | 1996-01-10 | — | — | EP | disclosed |