Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1B | P28222 | 9/20 | 0.46 |
| ▸ | HTR1D | P28221 | 8/20 | 0.46 |
| ▸ | HTR1A | P08908 | 3/20 | 0.46 |
| ▸ | DRD3 | P35462 | 1/20 | 0.45 |
| ▸ | FYN | P06241 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7443429 | 0.84 | HTR1D (0.53) | HTR1BHTR1DHTR1AFYN | |
| SCHEMBL7445758 | 0.77 | HTR1D (0.62) | HTR1BHTR1DHTR1AFYN | |
| SCHEMBL7439655 | 0.73 | HTR1A (0.48) | HTR1BHTR1DHTR1ADRD3FYN | |
| SCHEMBL7445238 | 0.71 | HTR1A (0.50) | HTR1BHTR1DHTR1AFYN | |
| SCHEMBL8890741 | 0.70 | HTR1A (0.67) | HTR1BHTR1DHTR1A | |
| SCHEMBL8730331 | 0.66 | IMPDH2 (0.65) | FYN | |
| SCHEMBL8694462 | 0.66 | DRD3 (0.58) | HTR1ADRD3FYN | |
| SCHEMBL8689188 | 0.66 | ALDH1A1 (0.73) | FYN | |
| SCHEMBL8688812 | 0.66 | DRD3 (1.00) | HTR1ADRD3FYN | |
| SCHEMBL7458753 | 0.66 | FYN (0.58) | HTR1ADRD3FYN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5639778-A | TREATING CENTRAL NERVOUS SYSTEM DISORDERS | PHARMACIA & UPJOHN COMPANY (US) | 1997-06-17 | — | — | US | disclosed |
| EP-0690843-A1 | INDOLETETRALINS HAVING DOPAMINERGIC ACTIVITY | PHARMACIA & UPJOHN COMPANY (US) | 1996-01-10 | — | — | EP | disclosed |
| WO-1994021608-A1 | INDOLETETRALINS HAVING DOPAMINERGIC ACTIVITY | THE UPJOHN COMPANY (US) | 1994-09-29 | — | — | WO | disclosed |