Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM3 | P20309 | 16/20 | 0.49 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | DRD4 | P21917 | 1/20 | 0.41 |
| ▸ | DRD3 | P35462 | 1/20 | 0.41 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9059607 | 0.86 | CHRM3 (0.47) | CHRM3MEN1ALDH1A1KMT2AATM | |
| SCHEMBL9059897 | 0.86 | ALDH1A1 (0.49) | CHRM3CHRM2CHRM1MEN1ALDH1A1 | |
| SCHEMBL9060154 | 0.84 | CHRM3 (0.47) | CHRM3CHRM2CHRM1MEN1ALDH1A1 | |
| SCHEMBL9059856 | 0.84 | CHRM3 (0.53) | CHRM3DRD2DRD4DRD3ALDH1A1 | |
| SCHEMBL9311426 | 0.84 | CHRM3 (0.51) | CHRM3DRD2DRD4DRD3CHRM2 | |
| SCHEMBL9537814 | 0.82 | CHRM3 (0.50) | CHRM3DRD2DRD4DRD3CHRM2 | |
| SCHEMBL9059576 | 0.82 | CHRM3 (0.44) | CHRM3NPC1MEN1ALDH1A1KMT2A | |
| SCHEMBL9059243 | 0.80 | ALDH1A1 (0.46) | CHRM3CHRM2CHRM1MEN1ALDH1A1 | |
| SCHEMBL9538982 | 0.76 | CHRM3 (0.47) | CHRM3ALDH1A1KMT2A | |
| Fumaric Acid SCHEMBL9312680 | 0.74 | KDM4E (0.45) | CHRM3NPC1MEN1ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1996017612-A1 | USE OF SUBSTITUTED PHENYLAMIDINE AND PHENYLGUANIDINE COMPOUNDS FOR THE TREATMENT OF CEREBRAL AND CARDIAC ISCHAEMIA, CONVULSION AND SICKLE CELL ANAEMIA | KNOLL AKTIENGESELLSCHAFT (DE) | 1996-06-13 | — | — | WO | disclosed |
| EP-0536151-B1 | ORTHOSUBSTITUTED BIPHENYL GUANIDINE DERIVATIVES AND ANTIDIABETIC OR HYPOGLYCAEMIC AGENTS CONTAINING THEM | BOOTS CO PLC (GB) | 1994-09-14 | — | — | EP | disclosed |
| US-5302720-A | Biphenyl-substituted guanidine derivatives useful as hypoglycaemic agents | THE BOOTS COMPANY (GB) | 1994-04-12 | — | — | US | disclosed |
| WO-1992000273-A1 | ORTHOSUBSTITUTED BIPHENYL AMIDINE AND BIPHENYL GUANIDINE DERIVATIVES AND ANTIDIABETIC OR HYPOGLYCAEMIC AGENTS CONTAINING THEM | THE BOOTS COMPANY PLC (GB) | 1992-01-09 | — | — | WO | disclosed |