Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.47 |
| ▸ | SCN10A | Q9Y5Y9 | 6/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.43 |
| ▸ | SCN5A | Q14524 | 3/20 | 0.43 |
| ▸ | SCN1A | P35498 | 1/20 | 0.43 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.43 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.43 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | CHRNA7 | P36544 | 3/20 | 0.42 |
| ▸ | XDH | P47989 | 1/20 | 0.42 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9060849 | 0.98 | L3MBTL1 (0.48) | L3MBTL1CACNA2D1SCN10AKCNH2SCN5A | |
| SCHEMBL9060454 | 0.93 | L3MBTL1 (0.44) | L3MBTL1CACNA2D1SCN10AKCNH2SCN5A | |
| SCHEMBL1227954 | 0.88 | NPC1 (0.42) | L3MBTL1CACNA2D1SCN10AKCNH2SCN5A | |
| SCHEMBL9061793 | 0.88 | NPC1 (0.59) | L3MBTL1SCN10ANPC1RAB9AKDM4E | |
| SCHEMBL9061111 | 0.88 | NPC1 (0.51) | SCN10AKCNH2SCN5ASCN1ASCN9A | |
| SCHEMBL9060178 | 0.86 | NPC1 (0.57) | L3MBTL1SCN5ANPC1RAB9AKDM4E | |
| SCHEMBL9062349 | 0.86 | NPC1 (0.50) | SCN10AKCNH2SCN5ASCN1ASCN9A | |
| SCHEMBL9062115 | 0.85 | RXRA (0.48) | SCN10AKCNH2SCN5ASCN1ASCN9A | |
| SCHEMBL9061248 | 0.85 | NPC1 (0.56) | L3MBTL1NPC1RAB9AKDM4ESMN1; SMN2 | |
| SCHEMBL9062321 | 0.84 | RXRA (0.47) | SCN10AKCNH2SCN5ASCN1ASCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5536442-A | ELECTROOPTICS | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1996-07-16 | — | — | US | disclosed |
| US-5324449-A | Substituted phenyl trifluoromethyl ethers | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1994-06-28 | — | — | US | disclosed |
| EP-0334911-B1 | SUBSTITUTED PHENYLTRIFLUORMETHYLETHERS | MERCK PATENT GmbH (DE) | 1993-02-10 | — | — | EP | disclosed |
| EP-0334911-A1 | SUBSTITUTED PHENYLTRIFLUORMETHYLETHERS | MERCK PATENT GmbH (DE) | 1989-10-04 | — | — | EP | disclosed |