Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 1/20 | 0.48 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.48 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.48 |
| ▸ | CHRNA7 | P36544 | 4/20 | 0.46 |
| ▸ | SCN10A | Q9Y5Y9 | 7/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.44 |
| ▸ | SCN5A | Q14524 | 3/20 | 0.44 |
| ▸ | SCN1A | P35498 | 1/20 | 0.44 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.44 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.44 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9062321 | 0.98 | RXRA (0.47) | RXRAGRIN1GRIN2BCHRNA7SCN10A | |
| SCHEMBL9061400 | 0.94 | RXRA (0.44) | RXRAGRIN1GRIN2BCHRNA7SCN10A | |
| SCHEMBL9061509 | 0.91 | RXRA (0.46) | RXRAGRIN1GRIN2BCHRNA7SCN10A | |
| SCHEMBL5347935 | 0.89 | CHRNA7 (0.47) | RXRAGRIN1GRIN2BCHRNA7SCN10A | |
| SCHEMBL9341010 | 0.88 | NPC1 (0.40) | RXRAGRIN1GRIN2BCHRNA7SCN10A | |
| SCHEMBL9060808 | 0.88 | CHRNA7 (0.46) | RXRAGRIN1GRIN2BCHRNA7SCN10A | |
| SCHEMBL9062389 | 0.86 | RARB (0.50) | CHRNA7SCN10AKCNH2SCN5ASCN1A | |
| SCHEMBL9060474 | 0.85 | L3MBTL1 (0.49) | CHRNA7SCN10AKCNH2SCN5ASCN1A | |
| SCHEMBL507598 | 0.85 | KCNH2 (0.42) | SCN10AKCNH2SCN5ASCN1ASCN9A | |
| SCHEMBL19514109 | 0.85 | SCN10A (0.47) | SCN10AKCNH2SCN5ASCN1ASCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5536442-A | ELECTROOPTICS | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1996-07-16 | — | — | US | disclosed |
| US-5324449-A | Substituted phenyl trifluoromethyl ethers | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1994-06-28 | — | — | US | disclosed |
| EP-0334911-B1 | SUBSTITUTED PHENYLTRIFLUORMETHYLETHERS | MERCK PATENT GmbH (DE) | 1993-02-10 | — | — | EP | disclosed |
| EP-0334911-A1 | SUBSTITUTED PHENYLTRIFLUORMETHYLETHERS | MERCK PATENT GmbH (DE) | 1989-10-04 | — | — | EP | disclosed |