SCHEMBL9062255

SCHEMBL9062255

CCCOc1ccc(CCc2ccc(OC(F)(F)F)cc2)cc1

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 4/20 0.53
L3MBTL1 Q9Y468 3/20 0.53
TSHR P16473 1/20 0.46
DAO P14920 1/20 0.46
SLC6A4 P31645 3/20 0.44
SLC6A3 Q01959 3/20 0.44
ACACB O00763 1/20 0.43
GPR84 Q9NQS5 1/20 0.43
SLC5A1 P13866 1/20 0.43
SLC5A2 P31639 1/20 0.43
ALDH1A1 P00352 2/20 0.43
LTA4H P09960 1/20 0.43
CHRNB4 P30926 1/20 0.43
CHRNA3 P32297 1/20 0.43
CHRNA7 P36544 1/20 0.43
HTT P42858 1/20 0.43
HSD17B10 Q99714 1/20 0.43
CYP1A2 P05177 1/20 0.42
MAPK1 P28482 1/20 0.42
CYP2C19 P33261 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9061106 0.93 LMNA (0.48) LMNAL3MBTL1TSHRDAOALDH1A1
SCHEMBL2056113 0.91 L3MBTL1 (0.50) LMNAL3MBTL1TSHRLTA4HCYP1A2
SCHEMBL9061172 0.90 MEN1 (0.49) LMNAALDH1A1LTA4HMAPK1KMT2A
SCHEMBL9060848 0.89 NR5A1 (0.51) LMNATSHRALDH1A1LTA4HMAPK1
SCHEMBL9060451 0.89 NR5A1 (0.51) LMNATSHRALDH1A1LTA4HMAPK1
SCHEMBL2056313 0.86 HRH2 (0.50) L3MBTL1ACACBALDH1A1LTA4HHSD17B10
SCHEMBL9061152 0.86 L3MBTL1 (0.58) L3MBTL1TSHRDAOSLC6A4SLC6A3
SCHEMBL9060027 0.85 TSHR (0.51) LMNAL3MBTL1TSHRDAOSLC6A4
SCHEMBL9061635 0.84 RAB9A (0.46) LMNAL3MBTL1TSHRDAOACACB
SCHEMBL1687455 0.83 TSHR (0.53) LMNAL3MBTL1TSHRDAOSLC6A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5536442-A ELECTROOPTICS MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) 1996-07-16 US disclosed
US-5324449-A Substituted phenyl trifluoromethyl ethers MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) 1994-06-28 US disclosed
EP-0334911-B1 SUBSTITUTED PHENYLTRIFLUORMETHYLETHERS MERCK PATENT GmbH (DE) 1993-02-10 EP disclosed
EP-0334911-A1 SUBSTITUTED PHENYLTRIFLUORMETHYLETHERS MERCK PATENT GmbH (DE) 1989-10-04 EP disclosed