Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 4/20 | 0.63 |
| ▸ | BCHE | P06276 | 3/20 | 0.63 |
| ▸ | ACHE | P22303 | 3/20 | 0.63 |
| ▸ | HTR7 | P34969 | 5/20 | 0.52 |
| ▸ | HTR1A | P08908 | 3/20 | 0.50 |
| ▸ | DRD2 | P14416 | 1/20 | 0.50 |
| ▸ | DRD5 | P21918 | 1/20 | 0.50 |
| ▸ | DRD3 | P35462 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9051174 | 1.00 | MAOB (0.63) | MAOBBCHEACHEHTR7HTR1A | |
| SCHEMBL9048953 | 0.99 | MAOB (0.62) | MAOBBCHEACHEHTR7HTR1A | |
| SCHEMBL9049638 | 0.87 | MAOB (0.56) | MAOBBCHEACHE | |
| SCHEMBL9052662 | 0.87 | ACHE (0.63) | MAOBACHEHTR7HTR1ADRD2 | |
| SCHEMBL9049026 | 0.85 | MAOB (0.54) | MAOBBCHEACHE | |
| SCHEMBL9048736 | 0.85 | MAOB (0.54) | MAOBBCHEACHE | |
| SCHEMBL4500323 | 0.82 | MAOB (0.51) | MAOBBCHEACHEHTR7HTR1A | |
| SCHEMBL9047059 | 0.81 | MAOB (0.50) | MAOBBCHEACHEHTR7HTR1A | |
| SCHEMBL9056094 | 0.80 | MAOB (0.48) | MAOBBCHEACHE | |
| SCHEMBL13945586 | 0.79 | HTR7 (0.49) | HTR7HTR1ADRD2DRD5DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0703901-A1 | 1-SUBSTITUTED ISATIN AND OXINDOLE DERIVATIVES AS INHIBITORS OF ACETYLCHOLINESTERASE | Astra Aktiebolag (SE) | 1996-04-03 | — | — | EP | disclosed |
| WO-1994029272-A1 | 1-SUBSTITUTED ISATIN AND OXINDOLE DERIVATIVES AS INHIBITORS OF ACETYLCHOLINESTERASE | ASTRA AKTIEBOLAG (SE) | 1994-12-22 | — | — | WO | disclosed |