Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8854138 | 0.84 | POLB (0.33) | — | |
| Hydrochloric Acid SCHEMBL851748 | 0.83 | ACHE (0.31) | — | |
| Hydrochloric Acid SCHEMBL9562111 | 0.76 | BCHE (0.34) | — | |
| Biphenyl SCHEMBL18837049 | 0.73 | — | — | |
| Hydrochloric Acid SCHEMBL20440999 | 0.73 | — | — | |
| Hydrochloric Acid SCHEMBL8567414 | 0.65 | — | — | |
| SCHEMBL6142568 | 0.65 | MEN1 (0.30) | — | |
| Hydrochloric Acid SCHEMBL451011 | 0.64 | — | — | |
| Hydrochloric Acid SCHEMBL7027830 | 0.64 | — | — | |
| Hydrochloric Acid SCHEMBL8416144 | 0.64 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5587501-A | Process for the preparation of syndiotactic polyolefins having a broad molecular weight distribution | HOECHST AKTIENGESELLSCHAFT (DE) | 1996-12-24 | — | — | US | disclosed |
| US-5583192-A | POLYMERIZING A CYCLOOLEFIN AND AN OLEFIN IN THE PRESENCE OF A METALLOCENE CATALYST | HOECHST AKTIENGESELLSCHAFT (DE) | 1996-12-10 | — | — | US | disclosed |
| US-5539066-A | Process for the preparation of syndiotactic polyolefins having a broad molecular weight distribution | HOECHST AKTIENGESELLSCHAFT (DE) | 1996-07-23 | — | — | US | disclosed |