Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RNASE1 | P07998 | 1/20 | 0.38 |
| ▸ | TK1 | P04183 | 9/20 | 0.38 |
| ▸ | TK2 | O00142 | 7/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9755149 | 0.90 | RNASE1 (0.39) | RNASE1TK1TK2MAPK1HPGD | |
| SCHEMBL6301637 | 0.80 | RNASE1 (0.37) | RNASE1TK1TK2MAPK1 | |
| SCHEMBL6756343 | 0.77 | RNASE1 (0.36) | RNASE1TK1TK2MAPK1 | |
| SCHEMBL1706308 | 0.76 | RNASE1 (0.39) | RNASE1TK1TK2HPGD | |
| SCHEMBL28282990 | 0.74 | RNASE1 (0.38) | RNASE1TK1TK2HPGD | |
| SCHEMBL7640426 | 0.74 | RNASE1 (0.39) | RNASE1TK1TK2 | |
| SCHEMBL6753651 | 0.74 | RNASE1 (0.35) | RNASE1TK1TK2MAPK1 | |
| SCHEMBL1727535 | 0.73 | RNASE1 (0.40) | RNASE1TK1TK2 | |
| SCHEMBL6756344 | 0.73 | RNASE1 (0.37) | RNASE1TK1TK2HPGD | |
| SCHEMBL8200498 | 0.72 | RNASE1 (0.40) | RNASE1TK1TK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0649429-A4 | HETEROATOMIC OLIGONUCLEOSIDE LINKAGES. | ISIS PHARMACEUTICALS INC (US) | 1996-04-10 | — | — | EP | disclosed |
| EP-0649429-A1 | HETEROATOMIC OLIGONUCLEOSIDE LINKAGES | ISIS PHARMACEUTICALS, INC. (US) | 1995-04-26 | — | — | EP | disclosed |
| WO-1994000467-A1 | HETEROATOMIC OLIGONUCLEOSIDE LINKAGES | ISIS PHARMACEUTICALS, INC. (US) | 1994-01-06 | — | — | WO | disclosed |