Known targets — ChEMBL curated mechanism
DHFRGARTPTGFRPTGIRPTGS1PTGS2TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8envmurAthyA
The experimentally established mechanism targets of Tromethamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Propene SCHEMBL2376511 | 0.86 | TSHR (0.34) | — | |
| Tromethamine SCHEMBL10457365 | 0.77 | MEN1 (0.44) | MEN1LMNAKMT2A | |
| Tromethamine SCHEMBL14627560 | 0.76 | MEN1 (0.39) | MEN1LMNAKMT2A | |
| Tromethamine SCHEMBL10769870 | 0.75 | MEN1 (0.42) | MEN1LMNAKMT2A | |
| Tromethamine SCHEMBL10714882 | 0.74 | S1PR1 (0.40) | MEN1LMNAKMT2A | |
| Tromethamine SCHEMBL11159829 | 0.74 | S1PR1 (0.40) | MEN1LMNAKMT2A | |
| Tromethamine SCHEMBL11190547 | 0.74 | S1PR1 (0.40) | MEN1LMNAKMT2A | |
| Tromethamine SCHEMBL1548210 | 0.74 | S1PR1 (0.40) | MEN1LMNAKMT2A | |
| Tromethamine SCHEMBL593282 | 0.72 | MEN1 (0.43) | MEN1LMNAKMT2A | |
| Ethylene SCHEMBL6267949 | 0.72 | TSHR (0.37) | MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5556894-A | Flame resistant rigid polyurethane foams containing phosphorus and a halogen | BASF CORPORATION (US) | 1996-09-17 | — | — | US | claimed |
| EP-3512896-A1 | METHOD FOR REDUCING THE ALDEHYDE EMISSIONS OF POLYURETHANE FOAMS | Covestro Deutschland AG (DE) | 2019-07-24 | — | — | EP | disclosed |