Known targets — ChEMBL curated mechanism
DHFRGARTPTGFRPTGIRPTGS1PTGS2TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8envmurAthyA
The experimentally established mechanism targets of Tromethamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10442889 | 0.81 | — | — | |
| Hydrochloric Acid SCHEMBL11230311 | 0.78 | ALDH1A1 (0.53) | ALDH1A1TP53 | |
| Ethylene SCHEMBL11764647 | 0.76 | — | — | |
| Tromethamine SCHEMBL10457365 | 0.75 | MEN1 (0.44) | MEN1LMNAKMT2AALDH1A1 | |
| Tromethamine SCHEMBL14627560 | 0.74 | MEN1 (0.39) | MEN1LMNAKMT2A | |
| Tromethamine SCHEMBL11159829 | 0.72 | S1PR1 (0.40) | MEN1LMNAKMT2A | |
| Tromethamine SCHEMBL1548210 | 0.72 | S1PR1 (0.40) | MEN1LMNAKMT2A | |
| Tromethamine SCHEMBL11190547 | 0.72 | S1PR1 (0.40) | MEN1LMNAKMT2A | |
| Tromethamine SCHEMBL9065085 | 0.72 | MEN1 (0.37) | MEN1LMNAKMT2A | |
| Tromethamine SCHEMBL11542715 | 0.70 | MEN1 (0.43) | MEN1LMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 123 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116773728-A | Method for determining organic phosphotriester and its precursor and metabolite in environment medium | 南开大学 | 2023-09-19 | — | — | CN | claimed |
| CN-113161610-B | Non-aqueous electrolyte for lithium ion battery and lithium ion battery comprising same | 松山湖材料实验室 | 2022-07-22 | — | — | CN | claimed |
| CN-113224386-B | Cobalt acid lithium battery electrolyte additive, electrolyte and battery thereof | 松山湖材料实验室 | 2022-07-22 | — | — | CN | claimed |
| CN-112374943-B | Soil activator and preparation method thereof | 甘肃省农业科学院植物保护研究所 | 2022-06-07 | — | — | CN | claimed |
| CN-113224386-A | Cobalt acid lithium battery electrolyte additive, electrolyte and battery thereof | 松山湖材料实验室 | 2021-08-06 | — | — | CN | claimed |
| CN-113161610-A | Non-aqueous electrolyte for lithium ion battery and lithium ion battery comprising same | 松山湖材料实验室 | 2021-07-23 | — | — | CN | claimed |
| CN-108558941-B | Method for preparing 2-chloroethyl phosphoric acid di (2-chloroethyl) ester through rearrangement reaction | 江苏禾裕泰化学有限公司 | 2020-10-09 | — | — | CN | claimed |
| US-20120205591-A1 | SELF INDICATING RADIATION ALERT DOSIMETER | PATEL GORDHABHAI N (US) | 2012-08-16 | — | — | US | claimed |
| EP-1228901-B1 | Tire having non-black colored tread | GOODYEAR TIRE & RUBBER (US) | 2007-03-21 | — | — | EP | claimed |
| EP-1313823-A4 | PHOSPHITE COKE INHIBITORS FOR EDC-VCM FURNACES | ONDEO NALCO ENERGY SERV LP (US) | 2006-04-05 | — | — | EP | claimed |
| US-20020174924-A1 | Rubber tread of a lug and groove configuration and of a co-extruded cap/base construction; tread cap is black and a visible surface of at least one groove is a color other than black | GOODYEAR TIRE & RUBBER COMPANY, THE | 2002-11-28 | — | — | US | claimed |
| US-20020147257-A1 | Tire having colored tread | GOODYEAR TIRE & RUBBER COMPANY, THE | 2002-10-10 | — | — | US | claimed |
| US-20020144761-A1 | Tire having tread with colored sidewall in connection with a plurality of colored tread grooves | GOODYEAR TIRE & RUBBER COMPANY, THE | 2002-10-10 | — | — | US | claimed |
| US-20020143084-A1 | Halogenated isobutylene copolymer elastomer which contains silica reinforcement and an organo phosphite and article of manufacture, including a tire, having at least one component comprised of such rubber composition | GOODYEAR TIRE & RUBBER COMPANY, THE | 2002-10-03 | — | — | US | claimed |
| US-20020143095-A1 | Pneumatic tire is having a multi-colored tread of a cap/base construction | GOODYEAR TIRE & RUBBER COMPANY, THE | 2002-10-03 | — | — | US | claimed |
| EP-1228901-A2 | Tire having non-black colored tread | THE GOODYEAR TIRE & RUBBER COMPANY (US) | 2002-08-07 | — | — | EP | claimed |
| EP-1228900-A2 | PNEUMATIC TIRE HAVING DUAL AIR RETENTION QUASI ENVELOPES | THE GOODYEAR TIRE & RUBBER COMPANY (US) | 2002-08-07 | — | — | EP | claimed |
| WO-2002014454-A1 | PHOSPHITE COKE INHIBITORS FOR EDC-VCM FURNACES | ONDEO NALCO ENERGY SERVICES, L.P. (US) | 2002-02-21 | — | — | WO | claimed |
| EP-0535166-B1 | STABILIZED POLYMERIC COMPOSITIONS | RAYCHEM CORP (US) | 1998-04-01 | — | — | EP | claimed |
| US-4180636-A | MAGNESIUM HALIDE, TITANIUM COMPOUND ELECTRON DONOR COMPOUND, TRIALKYL ALUMINUM CATALYST | SHOWA DENKO KABUSHIKI KAISHA (JP) | 1979-12-25 | — | — | US | claimed |