Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 15/20 | 0.69 |
| ▸ | EDNRB | P24530 | 11/20 | 0.69 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7850015 | 1.00 | EDNRA (0.69) | EDNRAEDNRBMEN1CYP2C9TSHR | |
| SCHEMBL7224859 | 0.84 | EDNRB (0.68) | EDNRAEDNRB | |
| SCHEMBL9063022 | 0.84 | EDNRB (0.68) | EDNRAEDNRB | |
| SCHEMBL30844541 | 0.84 | EDNRA (0.68) | EDNRAEDNRB | |
| SCHEMBL8479988 | 0.83 | EDNRA (0.55) | EDNRAEDNRBTSHR | |
| SCHEMBL7716850 | 0.82 | EDNRA (1.00) | EDNRAEDNRBMEN1CYP2C9TSHR | |
| SCHEMBL8476607 | 0.82 | EDNRA (0.53) | EDNRAEDNRBTSHR | |
| SCHEMBL8481520 | 0.78 | EDNRA (0.50) | EDNRAEDNRBTSHR | |
| SCHEMBL7849998 | 0.77 | EDNRA (0.69) | EDNRAEDNRBMEN1CYP2C9TSHR | |
| SCHEMBL8479643 | 0.76 | TSHR (0.46) | EDNRAEDNRBTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0699191-A1 | SULFONAMIDES AND DERIVATIVES THEREOF THAT MODULATE THE ACTIVITY OF ENDOTHELIN | TEXAS BIOTECHNOLOGY CORPORATION (US) | 1996-03-06 | — | — | EP | disclosed |
| WO-1994027979-A1 | SULFONAMIDES AND DERIVATIVES THEREOF THAT MODULATE THE ACTIVITY OF ENDOTHELIN | IMMUNOPHARMACEUTICS, INC. (US) | 1994-12-08 | — | — | WO | disclosed |