Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 12/20 | 0.53 |
| ▸ | EDNRB | P24530 | 10/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.43 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8479988 | 0.92 | EDNRA (0.55) | EDNRAEDNRBTSHRMAPK1ALDH1A1 | |
| SCHEMBL8481520 | 0.89 | EDNRA (0.50) | EDNRAEDNRBTSHRMAPK1HSD11B1 | |
| SCHEMBL8478164 | 0.86 | HSD11B1 (0.49) | EDNRAEDNRBHSD11B1 | |
| SCHEMBL8479975 | 0.85 | EDNRA (0.66) | EDNRAEDNRB | |
| SCHEMBL8473239 | 0.82 | EDNRA (0.52) | EDNRAEDNRBTSHRMAPK1ALDH1A1 | |
| SCHEMBL9065130 | 0.82 | EDNRA (0.69) | EDNRAEDNRBTSHR | |
| SCHEMBL7850015 | 0.82 | EDNRA (0.69) | EDNRAEDNRBTSHR | |
| SCHEMBL8481482 | 0.81 | TSHR (0.45) | EDNRAEDNRBTSHRMAPK1CA12 | |
| SCHEMBL8523604 | 0.79 | EDNRA (0.51) | EDNRAEDNRBTSHRMAPK1 | |
| SCHEMBL8477061 | 0.79 | EDNRA (0.50) | EDNRAEDNRBTSHRMAPK1HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5859257-A | ANTIINFLAMMATORY, ANTIARTHRITIC AGENTS | G. D. SEARLE & CO. (US) | 1999-01-12 | — | — | US | disclosed |