Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 5/20 | 0.72 |
| ▸ | DRD2 | P14416 | 5/20 | 0.72 |
| ▸ | ABCB1 | P08183 | 12/20 | 0.69 |
| ▸ | LTA4H | P09960 | 1/20 | 0.54 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.54 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.51 |
| ▸ | DHFR | P00374 | 1/20 | 0.50 |
| ▸ | MGLL | Q99685 | 1/20 | 0.50 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.50 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.50 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.50 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4183309 | 0.84 | HTR1A (1.00) | HTR1ADRD2ABCB1ABCG2PTGER1 | |
| SCHEMBL17197391 | 0.80 | HTR1A (0.79) | HTR1ADRD2ABCB1ABCG2MGLL | |
| SCHEMBL31060779 | 0.78 | ABCB1 (1.00) | HTR1ADRD2ABCB1ABCG2 | |
| SCHEMBL9057460 | 0.77 | HTR1A (0.79) | HTR1ADRD2ABCB1ABCG2MGLL | |
| SCHEMBL1412912 | 0.77 | HTR1A (0.73) | HTR1ADRD2ABCB1LTA4HMGLL | |
| SCHEMBL23881745 | 0.77 | HTR1A (0.73) | HTR1ADRD2ABCB1ABCG2MGLL | |
| SCHEMBL3268053 | 0.77 | HTR1A (0.73) | HTR1ADRD2ABCB1ABCG2MGLL | |
| SCHEMBL7616541 | 0.77 | HTR1A (0.73) | HTR1ADRD2ABCB1ABCG2MGLL | |
| SCHEMBL10784832 | 0.77 | HTR1A (0.73) | HTR1ADRD2ABCB1ABCG2MGLL | |
| SCHEMBL4268295 | 0.77 | HTR1A (0.73) | HTR1ADRD2ABCB1ABCG2MGLL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0733033-A1 | PHARMACEUTICALLY ACTIVE SUBSTITUTED AROMATIC COMPOUNDS | ZENECA LIMITED (GB) | 1996-09-25 | — | — | EP | disclosed |