Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 10/20 | 0.66 |
| ▸ | DRD3 | P35462 | 6/20 | 0.62 |
| ▸ | HTR1A | P08908 | 5/20 | 0.62 |
| ▸ | HRH1 | P35367 | 4/20 | 0.62 |
| ▸ | HTR2A | P28223 | 3/20 | 0.62 |
| ▸ | HTR2C | P28335 | 3/20 | 0.62 |
| ▸ | HTR7 | P34969 | 3/20 | 0.62 |
| ▸ | HTR2B | P41595 | 3/20 | 0.62 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.61 |
| ▸ | DRD4 | P21917 | 4/20 | 0.58 |
| ▸ | DRD1 | P21728 | 3/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.56 |
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.56 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.56 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.56 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.56 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.56 |
| ▸ | MCHR1 | Q99705 | 3/20 | 0.56 |
| ▸ | DRD5 | P21918 | 2/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11415059 | 0.86 | MEN1 (0.76) | DRD2DRD3HTR1AHTR2AADRA1A | |
| SCHEMBL22778808 | 0.86 | HTR1A (0.76) | DRD2DRD3HTR1AHRH1HTR2A | |
| SCHEMBL11621419 | 0.85 | DRD2 (0.65) | DRD2DRD3HTR1AHRH1HTR2A | |
| Hydrochloric Acid SCHEMBL11635528 | 0.84 | ADRA1D (0.66) | DRD2DRD3HTR1AHRH1HTR2A | |
| SCHEMBL11829762 | 0.84 | DRD2 (0.70) | DRD2DRD3HTR1AHRH1HTR2A | |
| Hydrochloric Acid SCHEMBL11617320 | 0.84 | DRD2 (0.63) | DRD2DRD3HTR1AHRH1HTR2A | |
| SCHEMBL11562987 | 0.82 | DRD2 (0.68) | DRD2DRD3HTR1AHRH1HTR2A | |
| SCHEMBL21748552 | 0.82 | KMT2A (0.51) | DRD2KMT2AMEN1ALDH1A1MAPT | |
| SCHEMBL3868713 | 0.80 | DRD2 (0.76) | DRD2DRD3DRD4MCHR1 | |
| SCHEMBL6053511 | 0.80 | DRD2 (1.00) | DRD2DRD3HTR1AHRH1HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5578611-A | ANTITUMOR AGENTS AND PROSTATE TUMOR DETECTION BY BINDING HUMAN ALPHA-ADRENERGIC RECEPTOR AND HISTAMINE H1 RECEPTORS | SYNAPTIC PHARMACEUTICAL CORPORATION (US) | 1996-11-26 | — | — | US | disclosed |