Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | GAK | O14976 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.37 |
| ▸ | FLT3 | P36888 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | AHR | P35869 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | GRM5 | P41594 | 1/20 | 0.35 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL906788 | 0.80 | HPGD (0.41) | NAMPTGAKALDH1A1HPGDMAPK10 | |
| SCHEMBL21604053 | 0.66 | KDM4E (0.76) | MAPTKDM4EHSD17B10ALDH1A1HPGD | |
| SCHEMBL9082354 | 0.64 | ALDH1A1 (0.47) | MAPTKDM4EALDH1A1HPGDMAPK1 | |
| SCHEMBL1837920 | 0.64 | GRM1 (0.56) | MAPTKDM4EALDH1A1HPGDGAA | |
| SCHEMBL906710 | 0.63 | KDR (0.33) | KDM4EHSD17B10ALDH1A1HPGD | |
| SCHEMBL14680529 | 0.61 | ALDH1A1 (0.63) | MAPTKDM4EHSD17B10ALDH1A1HPGD | |
| SCHEMBL3580813 | 0.61 | NPC1 (0.60) | MAPTHSD17B10ALDH1A1L3MBTL1SMN1; SMN2 | |
| SCHEMBL24426878 | 0.61 | KDM4E (0.64) | MAPTKDM4EHSD17B10ALDH1A1HPGD | |
| SCHEMBL19439102 | 0.60 | HPGD (0.57) | NAMPTHPGDADORA2BL3MBTL1AHR | |
| SCHEMBL11355652 | 0.60 | HPGD (0.53) | KDM4EHPGDADORA2BL3MBTL1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2276759-B1 | 3-INDAZOLYL-4-PYRIDYLISOTHIAZOLES | LILLY CO ELI (US) | 2011-10-19 | — | — | EP | disclosed |
| US-7932274-B2 | 3-indazolyl-4-pyridylisothiazoles | ELI LILLY AND COMPANY (US) | 2011-04-26 | — | — | US | disclosed |
| EP-2276759-A1 | 3-INDAZOLYL-4-PYRIDYLISOTHIAZOLES | Eli Lilly & Company (US) | 2011-01-26 | — | — | EP | disclosed |