Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | GAK | O14976 | 1/20 | 0.38 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | FLT3 | P36888 | 1/20 | 0.37 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.37 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.37 |
| ▸ | ABL1 | P00519 | 1/20 | 0.37 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.36 |
| ▸ | NAMPT | P43490 | 1/20 | 0.36 |
| ▸ | AHR | P35869 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL906599 | 0.80 | NAMPT (0.39) | HPGDMAPK10L3MBTL1GAKMEN1 | |
| SCHEMBL1837920 | 0.78 | GRM1 (0.56) | HPGDMEN1KMT2ASMN1; SMN2LMNA | |
| SCHEMBL9082354 | 0.65 | ALDH1A1 (0.47) | HPGDMAPK10MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL11355652 | 0.64 | HPGD (0.53) | HPGDL3MBTL1ADORA3MEN1KMT2A | |
| SCHEMBL24992536 | 0.64 | HPGD (0.56) | HPGDL3MBTL1ADORA3MEN1KMT2A | |
| SCHEMBL30173006 | 0.64 | HPGD (0.56) | HPGDL3MBTL1ADORA3MEN1KMT2A | |
| SCHEMBL16986063 | 0.63 | GPR35 (0.38) | HPGDALDH1A1 | |
| SCHEMBL20270816 | 0.63 | SMN1; SMN2 (0.58) | MAPK10SMN1; SMN2 | |
| SCHEMBL19873324 | 0.63 | HPGD (0.61) | HPGDADORA3MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL3580813 | 0.62 | NPC1 (0.60) | L3MBTL1MEN1KMT2ASMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2276759-B1 | 3-INDAZOLYL-4-PYRIDYLISOTHIAZOLES | LILLY CO ELI (US) | 2011-10-19 | — | — | EP | disclosed |
| US-7932274-B2 | 3-indazolyl-4-pyridylisothiazoles | ELI LILLY AND COMPANY (US) | 2011-04-26 | — | — | US | disclosed |
| EP-2276759-A1 | 3-INDAZOLYL-4-PYRIDYLISOTHIAZOLES | Eli Lilly & Company (US) | 2011-01-26 | — | — | EP | disclosed |