Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | ABL1 | P00519 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 4/20 | 0.46 |
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.44 |
| ▸ | ADORA2B | P29275 | 5/20 | 0.43 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.43 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.43 |
| ▸ | GSK3B | P49841 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11358850 | 0.76 | L3MBTL1 (0.48) | ABL1RAB9ANPC1LMNASMN1; SMN2 | |
| SCHEMBL5345384 | 0.76 | HDAC3 (0.40) | LMNAMEN1KMT2AKDM4E | |
| SCHEMBL11355587 | 0.75 | ADORA3 (0.44) | HPGDRAB9ANPC1LMNASMN1; SMN2 | |
| SCHEMBL19873324 | 0.74 | HPGD (0.61) | HPGDABL1LMNASMN1; SMN2RXFP1 | |
| SCHEMBL11475387 | 0.71 | ADORA3 (0.41) | HPGDRAB9ANPC1LMNASMN1; SMN2 | |
| SCHEMBL11477427 | 0.71 | ALDH1A1 (0.39) | HPGDSMN1; SMN2L3MBTL1MEN1KMT2A | |
| SCHEMBL11475672 | 0.71 | TGM2 (0.44) | LMNA | |
| SCHEMBL11354448 | 0.71 | ALDH1A1 (0.44) | ABL1RAB9ANPC1LMNASMN1; SMN2 | |
| SCHEMBL11490856 | 0.71 | CA2 (0.40) | ABL1RAB9ANPC1SMN1; SMN2L3MBTL1 | |
| SCHEMBL22529508 | 0.70 | HPGD (0.51) | HPGDABL1RXFP1L3MBTL1ADORA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4183854-A | ANTIULCER OR ANTISECRETORY AGENT FOR MAMMALS | JOHN WYETH & BROTHER LIMITED (GB) | 1980-01-15 | — | — | US | claimed |
| US-4148904-A | 2-HALO-4-CARBOXAMIDE- OR CARBOXIMIDOTHIAZOLES | JOHN WYETH & BROTHER LIMITED (GB) | 1979-04-10 | — | — | US | claimed |
| US-4249012-A | ANTISECRETORY ANTIULCER AGENTS | JOHN WYETH & BROTHER LTD. (GB) | 1981-02-03 | — | — | US | disclosed |
| US-4183854-A | ANTIULCER OR ANTISECRETORY AGENT FOR MAMMALS | JOHN WYETH & BROTHER LIMITED (GB) | 1980-01-15 | — | — | US | disclosed |
| US-4148904-A | 2-HALO-4-CARBOXAMIDE- OR CARBOXIMIDOTHIAZOLES | JOHN WYETH & BROTHER LIMITED (GB) | 1979-04-10 | — | — | US | disclosed |
| US-4134984-A | AMIDO-SUBSTITUTED, ANTISECRETORY, ANTIULCER | JOHN WYETH & BROTHER LIMITED (GB) | 1979-01-16 | — | — | US | disclosed |