Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.36 |
| ▸ | CTSK | P43235 | 2/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | METAP2 | P50579 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | LTA4H | P09960 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9242481 | 0.84 | KDM4E (0.34) | ALDH1A1CTSKNPSR1METAP2KMT2A | |
| SCHEMBL7052790 | 0.83 | CTSK (0.36) | ALDH1A1CTSKNPSR1METAP2KMT2A | |
| SCHEMBL9242486 | 0.80 | CTSK (0.37) | ALDH1A1CTSKNPSR1METAP2KMT2A | |
| SCHEMBL2460306 | 0.76 | CYP2D6 (0.47) | ALDH1A1CTSKNPSR1METAP2KMT2A | |
| SCHEMBL9241538 | 0.76 | ALDH1A1 (0.41) | ALDH1A1CTSKMETAP2KMT2ATSHR | |
| SCHEMBL9246107 | 0.74 | ALDH1A1 (0.42) | ALDH1A1CTSKMETAP2KMT2ATSHR | |
| SCHEMBL9247556 | 0.74 | CTSK (0.33) | ALDH1A1CTSKNPSR1METAP2TSHR | |
| SCHEMBL9067738 | 0.73 | HDAC7 (0.38) | ALDH1A1NPSR1KMT2ATSHRL3MBTL1 | |
| SCHEMBL9241541 | 0.73 | ALDH1A1 (0.44) | ALDH1A1CTSKMETAP2KMT2ATSHR | |
| SCHEMBL9247550 | 0.73 | METAP2 (0.32) | ALDH1A1CTSKNPSR1METAP2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0726903-A1 | MATRIX METALLOPROTEASE INHIBITORS | SYNTEX INC (US) | 1996-08-21 | — | — | EP | disclosed |
| WO-1995012603-A1 | MATRIX METALLOPROTEASE INHIBITORS________________________________ | SYNTEX (U.S.A.) INC. (US) | 1995-05-11 | — | — | WO | disclosed |