Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 4/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.65 |
| ▸ | MAPT | P10636 | 4/20 | 0.59 |
| ▸ | MEN1 | O00255 | 2/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.59 |
| ▸ | USP2 | O75604 | 1/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.56 |
| ▸ | POLB | P06746 | 2/20 | 0.56 |
| ▸ | RECQL | P46063 | 2/20 | 0.56 |
| ▸ | APEX1 | P27695 | 1/20 | 0.56 |
| ▸ | BLM | P54132 | 1/20 | 0.51 |
| ▸ | DAO | P14920 | 6/20 | 0.48 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | LIG1 | P18858 | 1/20 | 0.44 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.44 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL68973 | 0.84 | HPGD (0.59) | HPGDKMT2AMAPTMEN1ALDH1A1 | |
| SCHEMBL1707142 | 0.83 | HPGD (0.61) | HPGDKMT2AMAPTMEN1ALDH1A1 | |
| SCHEMBL12411437 | 0.83 | DAO (0.50) | HPGDKMT2AMAPTMEN1ALDH1A1 | |
| SCHEMBL2332754 | 0.83 | MAPT (0.59) | HPGDKMT2AMAPTMEN1ALDH1A1 | |
| SCHEMBL11680962 | 0.82 | KMT2A (0.59) | HPGDKMT2AMAPTMEN1ALDH1A1 | |
| Methane SCHEMBL7759142 | 0.82 | HPGD (0.59) | HPGDKMT2AMAPTMEN1ALDH1A1 | |
| SCHEMBL4420125 | 0.80 | MAPT (0.58) | HPGDKMT2AMAPTMEN1ALDH1A1 | |
| SCHEMBL1401537 | 0.80 | DAO (0.50) | HPGDKMT2AMAPTMEN1ALDH1A1 | |
| SCHEMBL11299829 | 0.79 | HPGD (1.00) | HPGDKMT2AMAPTMEN1ALDH1A1 | |
| SCHEMBL7814255 | 0.79 | KMT2A (0.73) | HPGDKMT2AMAPTMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10626100-B2 | Selective HDAC6 inhibitors | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2020-04-21 | — | — | US | disclosed |
| US-10626100-B2 | Selective HDAC6 inhibitors | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2020-04-21 | — | — | US | disclosed |
| US-20180118709-A1 | SELECTIVE HDAC6 INHIBITORS | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2018-05-03 | — | — | US | disclosed |
| US-20180118709-A1 | SELECTIVE HDAC6 INHIBITORS | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2018-05-03 | — | — | US | disclosed |
| US-20180118709-A1 | SELECTIVE HDAC6 INHIBITORS | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2018-05-03 | — | — | US | disclosed |
| US-9890136-B2 | Selective HDAC6 inhibitors | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK MEMORIAL SLOAN-KETTERING CANCER CENTER (US) | 2018-02-13 | — | — | US | disclosed |
| US-9890136-B2 | Selective HDAC6 inhibitors | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK MEMORIAL SLOAN-KETTERING CANCER CENTER (US) | 2018-02-13 | — | — | US | disclosed |
| US-9890136-B2 | Selective HDAC6 inhibitors | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK MEMORIAL SLOAN-KETTERING CANCER CENTER (US) | 2018-02-13 | — | — | US | disclosed |
| US-20160347732-A1 | SELECTIVE HDAC6 INHIBITORS | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2016-12-01 | — | — | US | disclosed |
| US-20160347732-A1 | SELECTIVE HDAC6 INHIBITORS | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2016-12-01 | — | — | US | disclosed |
| US-20160347732-A1 | SELECTIVE HDAC6 INHIBITORS | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2016-12-01 | — | — | US | disclosed |
| WO-2015100363-A1 | SELECTIVE HDAC6 INHIBITORS | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2015-07-02 | — | — | WO | disclosed |
| US-5536724-A | Antiinflammatory and antineoplastic 5-deazaaminopterins and 5,10-dideazaaminopterins | SRI INTERNATIONAL (US) | 1996-07-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180118709-A1 | SELECTIVE HDAC6 INHIBITORS | HDAC7, HDAC6, HDAC3 | HPGD 4352/4885KMT2A 2766/4885MAPT 2497/4885 |
| US-20160347732-A1 | SELECTIVE HDAC6 INHIBITORS | HDAC7, HDAC6, HDAC3 | HPGD 4415/4885KMT2A 2843/4885MAPT 2256/4885 |
| US-10626100-B2 | Selective HDAC6 inhibitors | HDAC7, HDAC6, HDAC3 | HPGD 4352/4885KMT2A 2766/4885MAPT 2497/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.