SCHEMBL1707142

SCHEMBL1707142

CC(=O)c1ccc(CC(=O)O)s1

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HPGD P15428 5/20 0.61
KMT2A Q03164 5/20 0.61
ALDH1A1 P00352 5/20 0.60
RECQL P46063 3/20 0.60
LMNA P02545 3/20 0.60
PRNP P04156 1/20 0.60
RXFP1 Q9HBX9 1/20 0.60
MAPT P10636 6/20 0.56
MEN1 O00255 3/20 0.56
USP2 O75604 1/20 0.56
HSD17B10 Q99714 1/20 0.56
L3MBTL1 Q9Y468 5/20 0.53
TDP1 Q9NUW8 4/20 0.53
POLB P06746 3/20 0.53
APEX1 P27695 1/20 0.53
BLM P54132 1/20 0.53
GSK3B P49841 1/20 0.48
TSHR P16473 1/20 0.46
APOBEC3A P31941 1/20 0.41
APOBEC3G Q9HC16 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Methane SCHEMBL7759142 0.98 HPGD (0.59) HPGDKMT2AALDH1A1RECQLLMNA
SCHEMBL9067494 0.83 HPGD (0.65) HPGDKMT2AALDH1A1RECQLMAPT
SCHEMBL16294237 0.82 ALDH1A1 (0.51) HPGDKMT2AALDH1A1RECQLLMNA
SCHEMBL68973 0.80 HPGD (0.59) HPGDKMT2AALDH1A1RECQLLMNA
SCHEMBL2332754 0.79 MAPT (0.59) HPGDKMT2AALDH1A1RECQLLMNA
SCHEMBL10209862 0.79 HPGD (0.63) HPGDKMT2AALDH1A1RECQLLMNA
SCHEMBL5351604 0.79 ALDH1A1 (0.54) HPGDKMT2AALDH1A1RECQLLMNA
SCHEMBL1798146 0.79 ALDH1A1 (0.56) HPGDKMT2AALDH1A1RECQLLMNA
SCHEMBL11680962 0.78 KMT2A (0.59) HPGDKMT2AALDH1A1RECQLLMNA
SCHEMBL13838138 0.78 LMNA (0.88) HPGDKMT2AALDH1A1RECQLLMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 48 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7294642-B2 1,3-Diamino-2-hydroxypropane pro-drug derivatives ELAN PHARMACEUTICALS, INC. (US) 2007-11-13 US claimed
US-4153610-A Process for producing 5-carboxy-2-acetylthiophene SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1979-05-08 US claimed
US-4130566-A Process for producing 5-carboxy-2-acetylthiophene SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1978-12-19 US claimed
JP-53065870-A None JP disclosed
JP-53023963-A None JP disclosed
JP-53141264-A None JP disclosed
US-20260109673-A1 ACETYL-COA CARBOXYLASE MODULATORS MONSANTO TECHNOLOGY LLC (US) 2026-04-23 US disclosed
US-12448355-B2 Acetyl-CoA carboxylase modulators MONSANTO TECHNOLOGY LLC (US) 2025-10-21 US disclosed
US-20220340893-A1 BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES NUEVOLUTION A/S (DK) 2022-10-27 US disclosed
US-20210246106-A1 ACETYL-COA CARBOXYLASE MODULATORS MONSANTO TECHNOLOGY LLC (US) 2021-08-12 US disclosed
US-10995070-B2 Acetyl-CoA carboxylase modulators MONSANTO TECHNOLOGY LLC (US) 2021-05-04 US disclosed
US-4792612-A MEDICINE INTERMEDIATES SEITETSU KAGAKU CO., LTD. (JP) 1988-12-20 US disclosed
EP-0245835-A2 Novel thiophene derivatives and methods for producing the same SEITETSU KAGAKU CO., LTD. (JP) 1987-11-19 EP disclosed
US-4153610-A Process for producing 5-carboxy-2-acetylthiophene SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1979-05-08 US disclosed
US-4153610-A Process for producing 5-carboxy-2-acetylthiophene SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1979-05-08 US disclosed
US-4130566-A Process for producing 5-carboxy-2-acetylthiophene SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1978-12-19 US disclosed
US-4130566-A Process for producing 5-carboxy-2-acetylthiophene SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1978-12-19 US disclosed
JP-S53141264-A PREPARATION OF 5-CARBOXY-2-ACETYL THIOPHENE SUMITOMO CHEM CO LTD 1978-12-08 JP disclosed
JP-S5365870-A PREPARATION OF 5-CARBOXY-2-ACETYLTHIOPHENE SUMITOMO CHEM CO LTD 1978-06-12 JP disclosed
JP-S5323963-A INDUSTRIAL PREPARATION OF 5-CARBOXY-2-ACETYL THIOPHENE SUMITOMO CHEM CO LTD 1978-03-06 JP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210246106-A1 ACETYL-COA CARBOXYLASE MODULATORS ACACA, ACACB, ACAT2 HPGD 800/4885KMT2A 1738/4885ALDH1A1 1039/4885
US-12448355-B2 Acetyl-CoA carboxylase modulators ACACA, ACACB, ACAT2 HPGD 800/4885KMT2A 1738/4885ALDH1A1 1039/4885
US-10995070-B2 Acetyl-CoA carboxylase modulators ACACA, ACACB, ACAT2 HPGD 800/4885KMT2A 1738/4885ALDH1A1 1039/4885
US-20260109673-A1 ACETYL-COA CARBOXYLASE MODULATORS ACACA, ACACB, HACL2 HPGD 1847/4885KMT2A 3187/4885ALDH1A1 1026/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.