Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 5/20 | 0.66 |
| ▸ | PIM1 | P11309 | 4/20 | 0.46 |
| ▸ | IDO1 | P14902 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.45 |
| ▸ | ALPL | P05186 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | TTK | P33981 | 1/20 | 0.45 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.41 |
| ▸ | PIM2 | Q9P1W9 | 2/20 | 0.40 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.38 |
| ▸ | FLT1 | P17948 | 1/20 | 0.38 |
| ▸ | AURKA | O14965 | 1/20 | 0.38 |
| ▸ | ITK | Q08881 | 1/20 | 0.38 |
| ▸ | MAP2K4 | P45985 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | MAPKAPK3 | Q16644 | 1/20 | 0.38 |
| ▸ | MAPK6 | Q16659 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30316298 | 0.80 | LRRK2 (1.00) | LRRK2PIM1IDO1KDM4EALDH1A1 | |
| SCHEMBL1328336 | 0.80 | LRRK2 (1.00) | LRRK2PIM1IDO1KDM4EALDH1A1 | |
| SCHEMBL906852 | 0.74 | IDO1 (0.56) | LRRK2PIM1IDO1KDM4EALDH1A1 | |
| SCHEMBL5873123 | 0.74 | LRRK2 (0.64) | LRRK2PIM1IDO1KDM4EALDH1A1 | |
| SCHEMBL1672674 | 0.73 | IDO1 (0.78) | LRRK2IDO1KDM4EALDH1A1MAPK10 | |
| SCHEMBL11786969 | 0.72 | LRRK2 (0.76) | LRRK2PIM1IDO1KDM4EALDH1A1 | |
| SCHEMBL1287897 | 0.70 | LRRK2 (0.68) | LRRK2PIM1IDO1KDM4EALDH1A1 | |
| SCHEMBL10452107 | 0.69 | LRRK2 (0.62) | LRRK2IDO1KDM4EALDH1A1MAPK10 | |
| SCHEMBL9445892 | 0.67 | KDM4E (0.46) | KDM4EALDH1A1ALPLGAAHPGD | |
| SCHEMBL28376527 | 0.67 | LRRK2 (0.68) | LRRK2PIM1IDO1KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101959883-B | 3-indazolyl-4-pyridylisothiazoles | LILLY CO ELI | 2013-01-30 | — | — | CN | disclosed |
| CN-101959883-B | 3-indazolyl-4-pyridylisothiazoles | LILLY CO ELI | 2013-01-30 | — | — | CN | disclosed |
| EP-2276759-B1 | 3-INDAZOLYL-4-PYRIDYLISOTHIAZOLES | LILLY CO ELI (US) | 2011-10-19 | — | — | EP | disclosed |
| US-7932274-B2 | 3-indazolyl-4-pyridylisothiazoles | ELI LILLY AND COMPANY (US) | 2011-04-26 | — | — | US | disclosed |
| EP-2276759-A1 | 3-INDAZOLYL-4-PYRIDYLISOTHIAZOLES | Eli Lilly & Company (US) | 2011-01-26 | — | — | EP | disclosed |
| CN-101959883-A | 3-indazolyl-4-pyridylisothiazoles | LILLY CO ELI | 2011-01-26 | — | — | CN | disclosed |
| WO-2009123855-A1 | 3-INDAZOLYL-4-PYRIDYLISOTHIAZOLES | ELI LILLY AND COMPANY (US) | 2009-10-08 | — | — | WO | disclosed |