Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 3/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | ALPL | P05186 | 1/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
| ▸ | TTK | P33981 | 1/20 | 0.56 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.56 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.52 |
| ▸ | LRRK2 | Q5S007 | 5/20 | 0.51 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.46 |
| ▸ | NAMPT | P43490 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | AURKA | O14965 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.43 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | MAPK3 | P27361 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10533662 | 0.86 | IDO1 (0.74) | IDO1KDM4EALDH1A1ALPLGAA | |
| SCHEMBL906850 | 0.74 | LRRK2 (0.66) | IDO1KDM4EALDH1A1ALPLGAA | |
| SCHEMBL30768403 | 0.73 | ALDH1A1 (1.00) | IDO1KDM4EALDH1A1ALPLGAA | |
| SCHEMBL855531 | 0.73 | ALDH1A1 (1.00) | IDO1KDM4EALDH1A1ALPLGAA | |
| SCHEMBL1672674 | 0.71 | IDO1 (0.78) | IDO1KDM4EALDH1A1ALPLGAA | |
| SCHEMBL17178615 | 0.70 | ALDH1A1 (0.92) | IDO1KDM4EALDH1A1ALPLGAA | |
| SCHEMBL9202922 | 0.70 | IDO1 (0.58) | IDO1KDM4EALDH1A1ALPLGAA | |
| SCHEMBL6494488 | 0.70 | IDO1 (0.58) | IDO1KDM4EALDH1A1ALPLGAA | |
| SCHEMBL906854 | 0.70 | LRRK2 (0.50) | IDO1KDM4EALDH1A1ALPLGAA | |
| SCHEMBL11682161 | 0.69 | MKNK1 (0.63) | IDO1KDM4EALDH1A1ALPLGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101959883-B | 3-indazolyl-4-pyridylisothiazoles | LILLY CO ELI | 2013-01-30 | — | — | CN | disclosed |
| CN-101959883-B | 3-indazolyl-4-pyridylisothiazoles | LILLY CO ELI | 2013-01-30 | — | — | CN | disclosed |
| EP-2276759-B1 | 3-INDAZOLYL-4-PYRIDYLISOTHIAZOLES | LILLY CO ELI (US) | 2011-10-19 | — | — | EP | disclosed |
| US-7932274-B2 | 3-indazolyl-4-pyridylisothiazoles | ELI LILLY AND COMPANY (US) | 2011-04-26 | — | — | US | disclosed |
| EP-2276759-A1 | 3-INDAZOLYL-4-PYRIDYLISOTHIAZOLES | Eli Lilly & Company (US) | 2011-01-26 | — | — | EP | disclosed |
| CN-101959883-A | 3-indazolyl-4-pyridylisothiazoles | LILLY CO ELI | 2011-01-26 | — | — | CN | disclosed |
| WO-2009123855-A1 | 3-INDAZOLYL-4-PYRIDYLISOTHIAZOLES | ELI LILLY AND COMPANY (US) | 2009-10-08 | — | — | WO | disclosed |