SCHEMBL1287897

SCHEMBL1287897

c1cnc(-c2n[nH]c3ccccc23)nc1

nearest known ligand 0.68

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LRRK2 Q5S007 3/20 0.68
IDO1 P14902 3/20 0.62
KDM4E B2RXH2 3/20 0.62
GAA P10253 2/20 0.62
ALDH1A1 P00352 2/20 0.62
TTK P33981 2/20 0.62
ALPL P05186 1/20 0.62
HPGD P15428 1/20 0.62
MAPK10 P53779 1/20 0.62
MAP2K4 P45985 2/20 0.53
ITK Q08881 2/20 0.50
FGFR1 P11362 1/20 0.50
FLT1 P17948 1/20 0.50
PDPK1 O15530 1/20 0.50
CYP3A4 P08684 1/20 0.50
AURKA O14965 1/20 0.50
MAPK1 P28482 1/20 0.49
MAPKAPK3 Q16644 1/20 0.49
MAPK6 Q16659 1/20 0.49
NPC1 O15118 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2029371 0.84 LRRK2 (0.54) LRRK2IDO1KDM4EGAAALDH1A1
SCHEMBL1672674 0.83 IDO1 (0.78) LRRK2IDO1KDM4EGAAALDH1A1
SCHEMBL1328336 0.81 LRRK2 (1.00) LRRK2IDO1KDM4EGAAALDH1A1
SCHEMBL30316298 0.81 LRRK2 (1.00) LRRK2IDO1KDM4EGAAALDH1A1
SCHEMBL10452107 0.79 LRRK2 (0.62) LRRK2IDO1KDM4EGAAALDH1A1
SCHEMBL855531 0.77 ALDH1A1 (1.00) LRRK2IDO1KDM4EGAAALDH1A1
SCHEMBL30768403 0.77 ALDH1A1 (1.00) LRRK2IDO1KDM4EGAAALDH1A1
SCHEMBL4219256 0.77 PDPK1 (0.54) LRRK2IDO1MAP2K4ITKFGFR1
SCHEMBL10533662 0.76 IDO1 (0.74) LRRK2IDO1KDM4EGAAALDH1A1
SCHEMBL17922026 0.76 LRRK2 (0.41) LRRK2IDO1KDM4EGAAALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 63 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2708556-B1 PHARMACEUTICAL COMPOSITION FOR THE USE IN A COMBINATION THERAPY FOR PREVENTION OR TREATMENT OF C-MET OR ANGIOGENESIS FACTOR INDUCED DISEASES SAMSUNG ELECTRONICS CO LTD (KR) 2018-11-07 EP claimed
US-9931400-B2 Method of combination therapy for prevention or treatment of c-Met or angiogenesis factor induced diseases SAMSUNG ELECTRONICS CO., LTD. (KR) 2018-04-03 US claimed
US-20140086926-A1 METHOD OF COMBINATION THERAPY FOR PREVENTION OR TREATMENT OF C-MET OR ANGIOGENESIS FACTOR INDUCED DISEASES SAMSUNG ELECTRONICS CO., LTD. (KR) 2014-03-27 US claimed
EP-2708556-A1 Pharmaceutical composition for the use in a combination therapy for prevention or treatment of C-Met or angiogenesis factor induced diseases Samsung Electronics Co., Ltd (KR) 2014-03-19 EP claimed
EP-4743106-A1 METHODS OF USING THE BRAIN-DERIVED OSTEOGENIC FACTOR CCN3 FOR TREATMENT OF BONE AND CARTILAGE DEGENERATION The Regents of University of California (US) 2026-05-20 EP disclosed
EP-4719365-A1 COMBINATION THERAPY WITH A MTOR INHIBITOR AND A MULTI-TYROSINE KINASE INHIBITOR FOR TREATING SOFT TISSUE SARCOMA Aadi Bioscience, Inc. (US) 2026-04-08 EP disclosed
WO-2025101807-A1 TREATMENT OF GLIOMAS WITH CHIMERIC ANTIGEN RECEPTOR T CELLS THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) 2025-05-15 WO disclosed
WO-2025049342-A1 METHODS OF USING THE BRAIN-DERIVED OSTEOGENIC FACTOR CCN3 FOR TREATMENT OF BONE AND CARTILAGE DEGENERATION THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2025-03-06 WO disclosed
US-20250074981-A1 COMBINATION THERAPY WITH DEXAMETHASONE AND TUMOR-SPECIFIC T CELL ENGAGING MULTI-SPECIFIC ANTIBODIES FOR TREATING CANCER NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2025-03-06 US disclosed
WO-2024243413-A1 COMBINATION THERAPY WITH A MTOR INHIBITOR AND A MULTI-TYROSINE KINASE INHIBITOR FOR TREATING SOFT TISSUE SARCOMA AADI BIOSCIENCE, INC. (US) 2024-11-28 WO disclosed
US-20240270854-A1 ENGINEERED BMP2 SURROGATE PROTEINS THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY 2024-08-15 US disclosed
US-20240181135-A1 BIOCHEMICAL ACTIVATION OF DYSFUNCTIONAL SKELETAL STEM CELLS FOR SKELETAL REGENERATION THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY 2024-06-06 US disclosed
WO-2009140549-A1 COMBINATIONS VEGF(R) INHIBITORS AND HEPATOCYTE GROWTH FACTOR (C-MET) INHIBITORS FOR THE TREATMENT OF CANCER AMGEN INC. (US) 2009-11-19 WO disclosed
EP-1976529-A4 ANG2 AND VEGF INHIBITOR COMBINATIONS AMGEN INC (US) 2009-07-22 EP disclosed
CN-101374522-A ANG2 and VEGF inhibitor combinations AMGEN INC (US) 2009-02-25 CN disclosed
EP-1976529-A2 ANG2 AND VEGF INHIBITOR COMBINATIONS Amgen Inc. (US) 2008-10-08 EP disclosed
EP-1915151-A2 COMBINATIONS FOR THE TREATMENT OF CANCER COMPRISING ANTI-EGFR ANTIBODY AND VEGFR INHIBITORS Amgen, Inc (US) 2008-04-30 EP disclosed
WO-2007089445-A2 ANG2 AND VEGF INHIBITOR COMBINATIONS AMGEN INC. (US) 2007-08-09 WO disclosed
WO-2006102504-A2 COMBINATIONS FOR THE TREATMENT OF CANCER COMPRISING ANTI-EGFR ANTIBODY AND VEGFR INHIBITORS AMGEN INC (US) 2006-09-28 WO disclosed
US-20060216288-A1 Combinations for the treatment of cancer AMGEN INC (US) 2006-09-28 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060216288-A1 Combinations for the treatment of cancer TP53, VHL, FOLR2 LRRK2 4710/4885IDO1 3718/4885KDM4E 3077/4885
US-20240270854-A1 ENGINEERED BMP2 SURROGATE PROTEINS BMP2, BMPR1A, BMPR2 LRRK2 1261/4885IDO1 1133/4885KDM4E 3847/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.