Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP1 | P29466 | 15/20 | 0.60 |
| ▸ | MME | P08473 | 1/20 | 0.55 |
| ▸ | ECE1 | P42892 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.54 |
| ▸ | CTSK | P43235 | 3/20 | 0.53 |
| ▸ | CTSL | P07711 | 1/20 | 0.52 |
| ▸ | CTSB | P07858 | 1/20 | 0.52 |
| ▸ | CTSS | P25774 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL613386 | 0.93 | CASP1 (0.67) | CASP1MMEECE1 | |
| SCHEMBL554032 | 0.93 | CASP1 (0.67) | CASP1MMEECE1 | |
| SCHEMBL376886 | 0.93 | CASP1 (0.67) | CASP1MMEECE1 | |
| SCHEMBL9069236 | 0.88 | CASP1 (0.59) | CASP1MMEECE1 | |
| SCHEMBL10605640 | 0.88 | PPARA (0.62) | CASP1MMEECE1 | |
| SCHEMBL10789378 | 0.88 | MME (0.62) | CASP1MMEECE1CTSK | |
| SCHEMBL7318257 | 0.88 | ALDH1A1 (0.65) | ALDH1A1ALOX15CTSKCTSLCTSB | |
| SCHEMBL13007019 | 0.87 | CASP1 (0.64) | CASP1ALDH1A1ALOX15CTSKCTSL | |
| SCHEMBL15381004 | 0.87 | CASP1 (0.64) | CASP1ALDH1A1ALOX15CTSKCTSL | |
| SCHEMBL4405472 | 0.87 | ALDH1A1 (0.57) | CASP1ALDH1A1ALOX15CTSKCTSL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1504462-A | Pyrimidinyl derivatives as interleukin inhibitors | ������˹ҩƷ��˾ | 2004-06-16 | — | — | CN | disclosed |
| CN-1118458-C | Pyrimidinyl derivatives as interleukin inhibitors | FERTERX PHARMACEUTICAL INC (US) | 2003-08-20 | — | — | CN | disclosed |
| CN-1149292-A | Pyrimidinyl derivatives as interleukin inhibitors | SANOFI WINTHROP INC (US) | 1997-05-07 | — | — | CN | disclosed |
| US-5585357-A | Heteroaryloxymethyl ketones as interleukin-1βconverting enzyme inhibitors | SANOFI WINTHROP INC. (US) | 1996-12-17 | — | — | US | disclosed |
| EP-0644198-A1 | Alpha-heteroaryloxymethyl ketones as interleukin-1beta converting enzyme inhibitors | STERLING WINTHROP INC. (US) | 1995-03-22 | — | — | EP | disclosed |