Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS1 | P29475 | 5/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.33 |
| ▸ | AKT1 | P31749 | 1/20 | 0.32 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.32 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.32 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.32 |
| ▸ | KDR | P35968 | 2/20 | 0.32 |
| ▸ | PLK4 | O00444 | 1/20 | 0.32 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.32 |
| ▸ | AURKA | O14965 | 1/20 | 0.32 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.32 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.32 |
| ▸ | CSF1R | P07333 | 1/20 | 0.32 |
| ▸ | RET | P07949 | 1/20 | 0.32 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.32 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.32 |
| ▸ | LTK | P29376 | 1/20 | 0.32 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9073237 | 0.80 | MAPT (0.38) | NOS1MAPTPIK3CAAKT1LRRK2 | |
| SCHEMBL9073146 | 0.76 | TGFBR1 (0.47) | MAPTLRRK2KDRAURKAMEN1 | |
| Hydrochloric Acid SCHEMBL9070445 | 0.75 | TGFBR1 (0.47) | MAPTLRRK2KDRAURKAMEN1 | |
| SCHEMBL3465347 | 0.74 | NOS1 (0.47) | NOS1AURKACSNK1A1PTK2CYP3A4 | |
| SCHEMBL9070472 | 0.74 | NOS1 (0.49) | NOS1MAPTDYRK1ALRRK2CLK4 | |
| SCHEMBL9370791 | 0.72 | MEN1 (0.46) | MAPTLRRK2KDM4EMEN1BLM | |
| SCHEMBL15590904 | 0.72 | MAPT (0.42) | NOS1MAPTDYRK1APIK3CALRRK2 | |
| SCHEMBL9073199 | 0.71 | ALDH1A1 (0.39) | MAPTCDK5ALDH1A1 | |
| SCHEMBL12480398 | 0.71 | NOS1 (0.52) | NOS1MAPTDYRK1ALRRK2CLK4 | |
| SCHEMBL10758608 | 0.70 | PARP1 (0.46) | MAPTDYRK1ALRRK2CLK4DYRK1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5506235-A | Quinoline derivatives as immunostimulants | PFIZER INC. (US) | 1996-04-09 | — | — | US | disclosed |
| EP-0597003-A1 | QUINOLINE DERIVATIVES AS IMMUNOSTIMULANTS | PFIZER INC. (US) | 1994-05-18 | — | — | EP | disclosed |
| WO-1993003030-A1 | QUINOLINE DERIVATIVES AS IMMUNOSTIMULANTS | PFIZER INC. (US) | 1993-02-18 | — | — | WO | disclosed |