Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | GCK | P35557 | 6/20 | 0.44 |
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | SCD | O00767 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.40 |
| ▸ | GRM5 | P41594 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9070812 | 0.91 | GCK (0.54) | POLBGCKNPC1RAB9AMAPT | |
| SCHEMBL2667552 | 0.89 | ALDH1A1 (0.43) | GCKNPC1RAB9AMAPTSCD | |
| SCHEMBL2667778 | 0.88 | GCK (0.49) | GCKNPC1RAB9ASCDSMN1; SMN2 | |
| SCHEMBL9070840 | 0.88 | ALDH1A1 (0.54) | POLBMAPTMAPK1SMN1; SMN2LMNA | |
| SCHEMBL2667348 | 0.84 | GCK (0.59) | GCKMAPK1ALDH1A1GRM5 | |
| SCHEMBL9070911 | 0.82 | GCK (0.46) | POLBGCKMAPTSCDMAPK1 | |
| SCHEMBL9070943 | 0.82 | GCK (0.45) | POLBGCKRAB9AMAPTSCD | |
| SCHEMBL2667351 | 0.81 | GCK (0.48) | GCKMAPTSCDMAPK1SMN1; SMN2 | |
| SCHEMBL2667566 | 0.81 | HRH3 (0.43) | GCKRAB9ASMN1; SMN2KDM4ELRRK2 | |
| SCHEMBL2667781 | 0.81 | GCK (0.50) | POLBGCKSCDGRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009083553-A1 | AZINE COMPOUNDS AS GLUCOKINASE ACTIVATORS | RHEOSCIENCE A/S (DK) | 2009-07-09 | — | — | WO | disclosed |