Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR6 | P46095 | 7/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.34 |
| ▸ | GCK | P35557 | 2/20 | 0.33 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.33 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | RORC | P51449 | 3/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2656912 | 0.80 | GPR6 (0.41) | GPR6PTGS2GCKRORCBRD4 | |
| SCHEMBL2668334 | 0.80 | GPR6 (0.41) | GPR6PTGS2GCKRORCBRD4 | |
| SCHEMBL13323747 | 0.78 | ALDH1A1 (0.42) | GCK | |
| SCHEMBL2655760 | 0.77 | GCK (0.38) | GPR6PTGS2GCKRORCBRD4 | |
| SCHEMBL2655226 | 0.76 | RAB9A (0.49) | GCK | |
| SCHEMBL2656938 | 0.76 | NPC1 (0.45) | PTGS2GCK | |
| SCHEMBL2655672 | 0.75 | BRD4 (0.49) | GCKBRD4 | |
| SCHEMBL2656341 | 0.75 | NPC1 (0.40) | GPR6PTGS2GCKRORCBRD4 | |
| SCHEMBL2656198 | 0.75 | GCK (0.50) | GCK | |
| SCHEMBL2657019 | 0.75 | PTGS2 (0.41) | GPR6PTGS2BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008104994-A2 | 2,2,2-TRI-SUBSTITUTED ACETAMIDE DERIVATIVES AS GLUCOKINASE ACTIVATORS, THEIR PROCESS AND PHARMACEUTICAL APPLICATION | ADVINUS THERAPEUTICS PRIVATE LIMITED (IN) | 2008-09-04 | — | — | WO | disclosed |