Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCK | P35557 | 5/20 | 0.53 |
| ▸ | RARA | P10276 | 1/20 | 0.53 |
| ▸ | RARB | P10826 | 1/20 | 0.53 |
| ▸ | RARG | P13631 | 1/20 | 0.53 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.51 |
| ▸ | NR1H4 | Q96RI1 | 3/20 | 0.41 |
| ▸ | PLAU | P00749 | 2/20 | 0.40 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.40 |
| ▸ | F2 | P00734 | 1/20 | 0.40 |
| ▸ | PLG | P00747 | 1/20 | 0.40 |
| ▸ | PLAT | P00750 | 1/20 | 0.40 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.40 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.40 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.39 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.39 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.39 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.39 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.39 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.39 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2666400 | 0.88 | PARP10 (0.49) | GCKRARARARBRARGPARP10 | |
| SCHEMBL14017929 | 0.87 | PARP10 (0.47) | GCKRARARARBRARGPARP10 | |
| SCHEMBL9071440 | 0.83 | PARP10 (0.50) | GCKPARP10PLAUF2PLG | |
| SCHEMBL13704013 | 0.83 | PARP10 (0.44) | GCKRARARARBRARGPARP10 | |
| SCHEMBL16950335 | 0.82 | GCK (0.50) | GCKRARARARBRARGNR1H4 | |
| SCHEMBL9071442 | 0.81 | PARP10 (0.47) | GCKRARARARBRARGPARP10 | |
| SCHEMBL14092358 | 0.81 | GCK (0.50) | GCKRARARARBRARGNR1H4 | |
| SCHEMBL14018037 | 0.81 | PARP10 (0.47) | GCKRARARARBRARGPARP10 | |
| SCHEMBL14018622 | 0.80 | PARP10 (0.56) | GCKPARP10NR1H4IRAK4ACACB | |
| SCHEMBL9071441 | 0.79 | PARP10 (0.53) | PARP10PLAUF2PLGPLAT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1529530-B3 | Compounds affecting glucokinase | ASTRAZENECA AB (SE) | 2009-09-02 | — | — | EP | disclosed |
| EP-1987831-A1 | COMPOUNDS EFFECTING GLUCOKINASE | AstraZeneca AB (SE) | 2008-11-05 | — | — | EP | disclosed |
| EP-1669068-B1 | Compounds effecting Glucokinase | ASTRAZENECA AB (SE) | 2008-06-11 | — | — | EP | disclosed |
| EP-1674097-B1 | Compounds effecting glucokinase | ASTRAZENECA AB (SE) | 2008-06-11 | — | — | EP | disclosed |
| EP-1661567-B1 | Compounds effecting Glucokinase | ASTRAZENECA AB (SE) | 2008-06-11 | — | — | EP | disclosed |
| EP-1568367-B1 | Compounds effecting glucokinase | ASTRAZENECA AB (SE) | 2007-04-18 | — | — | EP | disclosed |
| WO-2003015774-A1 | COMPOUNDS EFFECTING GLUCOKINASE | ASTRAZENECA AB (SE) | 2003-02-27 | — | — | WO | disclosed |