Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | XDH | P47989 | 2/20 | 0.49 |
| ▸ | HTR1A | P08908 | 1/20 | 0.47 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.47 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.47 |
| ▸ | MAOA | P21397 | 1/20 | 0.47 |
| ▸ | HTR2B | P41595 | 1/20 | 0.47 |
| ▸ | AR | P10275 | 1/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | IDO1 | P14902 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10203011 | 0.92 | SMN1; SMN2 (0.51) | MAPK1SMN1; SMN2ALDH1A1HTTXDH | |
| SCHEMBL6539807 | 0.83 | HTT (0.54) | MAPK1SMN1; SMN2ALDH1A1HTTXDH | |
| SCHEMBL28867053 | 0.83 | HTT (0.50) | MAPK1SMN1; SMN2ALDH1A1HTTXDH | |
| SCHEMBL1667585 | 0.82 | HTR1A (0.56) | MAPK1SMN1; SMN2ALDH1A1XDHHTR1A | |
| 1,2-Diisopentoxybenzene SCHEMBL2843498 | 0.81 | HTT (0.62) | MAPK1SMN1; SMN2ALDH1A1HTTKDM4E | |
| SCHEMBL27581075 | 0.81 | SMN1; SMN2 (0.48) | MAPK1SMN1; SMN2ALDH1A1HTTHTR1A | |
| SCHEMBL973234 | 0.80 | ALDH1A1 (0.54) | MAPK1SMN1; SMN2ALDH1A1HTR1AADRA2A | |
| SCHEMBL10991288 | 0.79 | HTR1B (0.57) | MAPK1SMN1; SMN2ALDH1A1HTR1AADRA2A | |
| SCHEMBL828475 | 0.79 | AR (0.53) | MAPK1SMN1; SMN2ALDH1A1HTR1AADRA2A | |
| SCHEMBL1444254 | 0.79 | CYP1A2 (0.55) | MAPK1SMN1; SMN2ALDH1A1HTR1AADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110070297-A1 | GLUCOKINASE ACTIVATORS | TAKEDA SAN DIEGO, INC. (US) | 2011-03-24 | — | — | US | disclosed |
| US-20110070297-A1 | GLUCOKINASE ACTIVATORS | TAKEDA SAN DIEGO, INC. (US) | 2011-03-24 | — | — | US | disclosed |
| US-20070197532-A1 | GLUCOKINASE ACTIVATORS | TAKEDA SAN DIEGO, INC. | 2007-08-23 | — | — | US | disclosed |
| US-20070197532-A1 | GLUCOKINASE ACTIVATORS | TAKEDA SAN DIEGO, INC. | 2007-08-23 | — | — | US | disclosed |
| WO-2007061923-A2 | GLUCOKINASE ACTIVATORS | TAKEDA SAN DIEGO, INC. (US) | 2007-05-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070197532-A1 | GLUCOKINASE ACTIVATORS | GCK, GCKR, GALK1 | MAPK1 1276/4885SMN1; SMN2 4119/4885ALDH1A1 1527/4885 |
| US-20110070297-A1 | GLUCOKINASE ACTIVATORS | GCK, GCKR, GALK1 | MAPK1 1276/4885SMN1; SMN2 4119/4885ALDH1A1 1527/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.