Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 2/20 | 0.55 |
| ▸ | F2 | P00734 | 1/20 | 0.51 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.49 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | HRH2 | P25021 | 1/20 | 0.47 |
| ▸ | HRH1 | P35367 | 1/20 | 0.47 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.47 |
| ▸ | CMA1 | P23946 | 6/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.46 |
| ▸ | CTSS | P25774 | 2/20 | 0.45 |
| ▸ | CTSL | P07711 | 1/20 | 0.45 |
| ▸ | CTSB | P07858 | 1/20 | 0.45 |
| ▸ | CTSK | P43235 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9074235 | 1.00 | ACE (0.55) | ACEF2PRSS1HDAC1HDAC8 | |
| SCHEMBL9077150 | 0.90 | ACE (0.51) | ACEF2PRSS1HDAC1HDAC8 | |
| SCHEMBL9077156 | 0.90 | ACE (0.51) | ACEF2PRSS1HDAC1HDAC8 | |
| SCHEMBL9077159 | 0.88 | F2 (0.51) | ACEF2PRSS1HDAC1HDAC8 | |
| SCHEMBL9076354 | 0.88 | ITGB3 (0.55) | ACEF2PRSS1HDAC1HDAC8 | |
| SCHEMBL9076357 | 0.88 | ITGB3 (0.55) | ACEF2PRSS1HDAC1HDAC8 | |
| SCHEMBL9414142 | 0.85 | ACE (0.51) | ACEF2PRSS1KMT2AHRH2 | |
| SCHEMBL9414140 | 0.85 | ACE (0.51) | ACEF2PRSS1KMT2AHRH2 | |
| SCHEMBL6171025 | 0.79 | ACE (0.64) | ACEF2PRSS1KMT2AHRH2 | |
| SCHEMBL6171028 | 0.79 | ACE (0.64) | ACEF2PRSS1KMT2AHRH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5583146-A | Heterocyclic thrombin inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 1996-12-10 | — | — | US | disclosed |
| EP-0623596-A1 | N-acylpyrrolidines or N-acylpiperidines having a guanidinyl- or amidinyl-substituted side chain as thrombin inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 1994-11-09 | — | — | EP | disclosed |