Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 1/20 | 0.51 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.51 |
| ▸ | ACE | P12821 | 1/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.47 |
| ▸ | CMA1 | P23946 | 7/20 | 0.46 |
| ▸ | HRH2 | P25021 | 1/20 | 0.45 |
| ▸ | HRH1 | P35367 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.43 |
| ▸ | CTRC | Q99895 | 2/20 | 0.43 |
| ▸ | PLG | P00747 | 1/20 | 0.43 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.43 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9074231 | 0.88 | ACE (0.55) | F2PRSS1ACEHDAC1HDAC8 | |
| SCHEMBL9074235 | 0.88 | ACE (0.55) | F2PRSS1ACEHDAC1HDAC8 | |
| SCHEMBL9077150 | 0.88 | ACE (0.51) | F2PRSS1ACEHDAC1HDAC8 | |
| SCHEMBL9077156 | 0.88 | ACE (0.51) | F2PRSS1ACEHDAC1HDAC8 | |
| SCHEMBL9076357 | 0.86 | ITGB3 (0.55) | F2PRSS1ACEHDAC1HDAC8 | |
| SCHEMBL9076354 | 0.86 | ITGB3 (0.55) | F2PRSS1ACEHDAC1HDAC8 | |
| SCHEMBL9076993 | 0.84 | DPP4 (0.50) | F2PRSS1 | |
| SCHEMBL9073722 | 0.78 | F2 (0.41) | F2PRSS1ACEPLG | |
| SCHEMBL9414142 | 0.77 | ACE (0.51) | F2PRSS1ACECMA1HRH2 | |
| SCHEMBL9414140 | 0.77 | ACE (0.51) | F2PRSS1ACECMA1HRH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5583146-A | Heterocyclic thrombin inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 1996-12-10 | — | — | US | disclosed |
| EP-0623596-A1 | N-acylpyrrolidines or N-acylpiperidines having a guanidinyl- or amidinyl-substituted side chain as thrombin inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 1994-11-09 | — | — | EP | disclosed |