Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNKS | O95271 | 2/20 | 0.40 |
| ▸ | PARP1 | P09874 | 2/20 | 0.40 |
| ▸ | TNKS2 | Q9H2K2 | 2/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | XBP1 | P17861 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12712581 | 1.00 | TNKS (0.40) | TNKSPARP1TNKS2SLC6A4SLC6A3 | |
| SCHEMBL11690543 | 0.94 | TNKS (0.43) | TNKSPARP1TNKS2SLC6A4SLC6A3 | |
| SCHEMBL11507049 | 0.89 | SLC6A4 (0.38) | TNKSPARP1TNKS2SLC6A4SLC6A3 | |
| SCHEMBL1350898 | 0.83 | TNKS (0.40) | TNKSPARP1TNKS2HTTLMNA | |
| SCHEMBL6491495 | 0.83 | RAB9A (0.42) | TNKSPARP1TNKS2SLC6A4SLC6A3 | |
| SCHEMBL11543844 | 0.82 | APP (0.43) | TNKSPARP1TNKS2HSD11B1USP2 | |
| SCHEMBL5777587 | 0.81 | SMN1; SMN2 (0.39) | HSD11B1RAB9AUSP2CYP3A4HTT | |
| SCHEMBL11493860 | 0.81 | ESR1 (0.50) | TNKSPARP1TNKS2SLC6A4SLC6A3 | |
| SCHEMBL31305572 | 0.81 | TSHR (0.46) | TNKSPARP1TNKS2RAB9AKMT2A | |
| SCHEMBL11510113 | 0.79 | TNKS (0.40) | TNKSPARP1TNKS2CYP3A4SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8288569-B2 | Carbonyl asymmetric alkylation | SANDOZ AG (CH) | 2012-10-16 | — | — | US | disclosed |
| EP-1966127-B1 | CARBONYL ASYMMETRIC ALKYLATION | SANDOZ AG (CH) | 2011-04-06 | — | — | EP | disclosed |
| US-20110009648-A1 | Carbonyl Asymmetric Alkylation | SANDOZ AG (CH) | 2011-01-13 | — | — | US | disclosed |
| EP-1966127-A1 | CARBONYL ASYMMETRIC ALKYLATION | Sandoz AG (CH) | 2008-09-10 | — | — | EP | disclosed |
| WO-2007082771-A1 | CARBONYL ASYMMETRIC ALKYLATION | SANDOZ AG (CH) | 2007-07-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110009648-A1 | Carbonyl Asymmetric Alkylation | COASY, ADH5, SI | TNKS 2120/4885PARP1 1033/4885TNKS2 2345/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.