Known targets — ChEMBL curated mechanism
GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BHMGCRMMP1MMP13MMP7MMP8PTGS1PTGS2ileSpolrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | PGK1 | P00558 | 1/20 | 0.30 |
| ▸ | PGK2 | P07205 | 1/20 | 0.30 |
| ▸ | LPAR5 | Q9H1C0 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4237 | 1.00 | SMN1; SMN2 (0.51) | SMN1; SMN2LMNAALDH1A1KDM4EDUSP3 | |
| Water SCHEMBL23706309 | 0.98 | SMN1; SMN2 (0.50) | SMN1; SMN2LMNAALDH1A1KDM4EDUSP3 | |
| Water SCHEMBL5432562 | 0.98 | SMN1; SMN2 (0.50) | SMN1; SMN2LMNAALDH1A1KDM4EDUSP3 | |
| SCHEMBL124155 | 0.98 | SMN1; SMN2 (0.53) | SMN1; SMN2LMNAALDH1A1KDM4EDUSP3 | |
| SCHEMBL16567918 | 0.98 | SMN1; SMN2 (0.53) | SMN1; SMN2LMNAALDH1A1KDM4EDUSP3 | |
| SCHEMBL4450401 | 0.98 | SMN1; SMN2 (0.53) | SMN1; SMN2LMNAALDH1A1KDM4EDUSP3 | |
| SCHEMBL21752929 | 0.95 | SMN1; SMN2 (0.51) | SMN1; SMN2LMNAALDH1A1KDM4EDUSP3 | |
| SCHEMBL21145174 | 0.95 | SMN1; SMN2 (0.51) | SMN1; SMN2LMNAALDH1A1KDM4EDUSP3 | |
| SCHEMBL21752847 | 0.95 | SMN1; SMN2 (0.51) | SMN1; SMN2LMNAALDH1A1KDM4EDUSP3 | |
| SCHEMBL21752876 | 0.95 | SMN1; SMN2 (0.51) | SMN1; SMN2LMNAALDH1A1KDM4EDUSP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0689445-A1 | ALUMINIUM CONTAINING PHARMACEUTICAL PREPARATION WITH CONTROLLED RELEASE | SYNEPOS AKTIENGESELLSCHAFT (LI) | 1996-01-03 | — | — | EP | claimed |
| WO-1994021268-A1 | ALUMINIUM CONTAINING PHARMACEUTICAL PREPARATION WITH CONTROLLED RELEASE | SYNEPOS AKTIENGESELLSCHAFT (LI) | 1994-09-29 | — | — | WO | claimed |
| WO-2013089565-A1 | IMPROVEMENTS IN ORAL HEALTH, PRODUCTS AND METHODS THEREFOR | ABDALLA HISHAM (NZ) | 2013-06-20 | — | — | WO | disclosed |
| EP-0689445-A1 | ALUMINIUM CONTAINING PHARMACEUTICAL PREPARATION WITH CONTROLLED RELEASE | SYNEPOS AKTIENGESELLSCHAFT (LI) | 1996-01-03 | — | — | EP | disclosed |
| WO-1994021268-A1 | ALUMINIUM CONTAINING PHARMACEUTICAL PREPARATION WITH CONTROLLED RELEASE | SYNEPOS AKTIENGESELLSCHAFT (LI) | 1994-09-29 | — | — | WO | disclosed |