SCHEMBL9075741

SCHEMBL9075741

Clc1ccc(Cc2ccc3[nH]ccc3c2)cc1

nearest known ligand 0.63

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
AHR P35869 4/20 0.63
NR4A2 P43354 2/20 0.63
F7 P08709 1/20 0.63
LTA4H P09960 1/20 0.63
F3 P13726 1/20 0.63
CYP17A1 P05093 1/20 0.54
CYP11B1 P15538 1/20 0.54
CYP11B2 P19099 1/20 0.54
CMA1 P23946 1/20 0.48
CYP19A1 P11511 2/20 0.46
CYP2A6 P11509 2/20 0.44
HDAC1 Q13547 1/20 0.44
HDAC8 Q9BY41 1/20 0.44
USP2 O75604 1/20 0.44
GAA P10253 1/20 0.44
ALOX15 P16050 1/20 0.44
RAD51 Q06609 1/20 0.44
NPSR1 Q6W5P4 1/20 0.44
NPC1 O15118 2/20 0.42
MAOB P27338 2/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8604113 0.84 CYP17A1 (0.55) AHRNR4A2F7LTA4HF3
SCHEMBL30030142 0.84 CYP17A1 (0.55) AHRNR4A2F7LTA4HF3
SCHEMBL30587351 0.78 AHR (1.00) AHRNR4A2F7LTA4HF3
SCHEMBL405311 0.78 AHR (1.00) AHRNR4A2F7LTA4HF3
SCHEMBL30375508 0.78 CYP17A1 (0.54) AHRNR4A2F7LTA4HF3
SCHEMBL30957581 0.77 AHR (0.61) AHRNR4A2F7LTA4HF3
SCHEMBL6582346 0.77 AHR (0.55) AHRNR4A2F7LTA4HF3
SCHEMBL16741873 0.77 ENPP2 (0.54) CYP17A1CYP11B1CYP11B2CYP2A6HDAC1
SCHEMBL30375430 0.77 LTA4H (0.51) AHRNR4A2F7LTA4HF3
SCHEMBL1572159 0.77 AHR (0.51) AHRNR4A2F7LTA4HF3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5506234-A PSYCHOPHARMACEUTICAL AGENTS WHICH BIND TO BENZODIAZEPINE RECEPTORS; ANXIOLYTIC AGENTS; MINIMAL SIDE EFFECTS SCHERING AKTIENGESELLSCHAFT (DE) 1996-04-09 US disclosed
EP-0557497-A1 NEW $g(b)-CARBOLIN DERIVATIVES, THEIR PREPARATION AND THEIR USE IN DRUGS SCHERING AKTIENGESELLSCHAFT (DE) 1993-09-01 EP disclosed
WO-1993006100-A1 NEW β-CARBOLIN DERIVATIVES, THEIR PREPARATION AND THEIR USE IN DRUGS SCHERING AKTIENGESELLSCHAFT (DE) 1993-04-01 WO disclosed