Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AOC3 | Q16853 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.36 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9078546 | 0.85 | SMN1; SMN2 (0.50) | AOC3TSHRL3MBTL1MAPK1HPGD | |
| SCHEMBL9079380 | 0.83 | CNR2 (0.40) | HRH3NR1H2 | |
| SCHEMBL9079241 | 0.80 | AOC3 (0.41) | AOC3TSHRL3MBTL1MAPK1HPGD | |
| Tetrazole SCHEMBL9079231 | 0.77 | POLB (0.41) | AOC3TSHRL3MBTL1MAPK1HPGD | |
| SCHEMBL7258758 | 0.77 | SMN1; SMN2 (0.52) | AOC3TSHRL3MBTL1MAPK1HPGD | |
| SCHEMBL10982252 | 0.77 | CYP4F2 (0.50) | ALDH1A1HRH3NR1H2NR1H3 | |
| SCHEMBL22384139 | 0.73 | TSHR (0.39) | TSHRHPGDHSD17B10SMN1; SMN2ALDH1A1 | |
| SCHEMBL10593325 | 0.73 | MAPK1 (0.57) | AOC3TSHRL3MBTL1MAPK1HPGD | |
| SCHEMBL9076427 | 0.73 | AOC3 (0.44) | AOC3TSHRL3MBTL1MAPK1HPGD | |
| SCHEMBL557206 | 0.73 | RXRA (0.59) | L3MBTL1HRH3LMNANR1H2NR1H3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5508437-A | APPETITE SUPPRESSANTS | HOFFMANN-LA ROCHE INC. (US) | 1996-04-16 | — | — | US | disclosed |
| US-5296608-A | Intermediates for analogs of tyrosine sulfate or tyrosine phosphate containing peptides | HOFFMAN-LA ROCHE INC. (US) | 1994-03-22 | — | — | US | disclosed |
| US-5182263-A | Appetite suppressants | HOFFMANN-LA ROCHE INC. (US) | 1993-01-26 | — | — | US | disclosed |
| EP-0339549-A2 | Tyr-peptide analogs | F. HOFFMANN-LA ROCHE AG (CH) | 1989-11-02 | — | — | EP | disclosed |