Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AOC3 | Q16853 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 3/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | MGLL | Q99685 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9078945 | 0.80 | AOC3 (0.47) | AOC3TSHRHSD17B10HPGDMAPK1 | |
| SCHEMBL9078546 | 0.78 | SMN1; SMN2 (0.50) | AOC3TSHRHSD17B10HPGDMAPK1 | |
| Tetrazole SCHEMBL9079231 | 0.76 | POLB (0.41) | AOC3TSHRHSD17B10HPGDMAPK1 | |
| SCHEMBL7258758 | 0.70 | SMN1; SMN2 (0.52) | AOC3TSHRHSD17B10HPGDMAPK1 | |
| SCHEMBL10593325 | 0.69 | MAPK1 (0.57) | AOC3TSHRHSD17B10HPGDMAPK1 | |
| SCHEMBL22256095 | 0.68 | TSHR (0.47) | AOC3TSHRHSD17B10HPGDMAPK1 | |
| SCHEMBL9079405 | 0.67 | AOC3 (0.47) | AOC3TSHRHSD17B10HPGDMAPK1 | |
| SCHEMBL8849307 | 0.67 | TSHR (0.56) | AOC3TSHRHSD17B10HPGDMAPK1 | |
| SCHEMBL20714306 | 0.65 | AOC3 (0.50) | AOC3TSHRMAPK1L3MBTL1SMN1; SMN2 | |
| SCHEMBL9079380 | 0.65 | CNR2 (0.40) | MGLL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5508437-A | APPETITE SUPPRESSANTS | HOFFMANN-LA ROCHE INC. (US) | 1996-04-16 | — | — | US | disclosed |
| EP-0339549-A2 | Tyr-peptide analogs | F. HOFFMANN-LA ROCHE AG (CH) | 1989-11-02 | — | — | EP | disclosed |