Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.39 |
| ▸ | RXRA | P19793 | 1/20 | 0.39 |
| ▸ | RXRB | P28702 | 1/20 | 0.39 |
| ▸ | RXRG | P48443 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | CASP3 | P42574 | 1/20 | 0.38 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.38 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.38 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.38 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.37 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9078546 | 0.88 | SMN1; SMN2 (0.50) | POLBSMN1; SMN2TSHRL3MBTL1MAPK1 | |
| SCHEMBL9078945 | 0.77 | AOC3 (0.47) | POLBSMN1; SMN2TSHRL3MBTL1MAPK1 | |
| SCHEMBL9079241 | 0.76 | AOC3 (0.41) | POLBSMN1; SMN2TSHRL3MBTL1MAPK1 | |
| SCHEMBL7258758 | 0.76 | SMN1; SMN2 (0.52) | POLBSMN1; SMN2TSHRL3MBTL1MAPK1 | |
| SCHEMBL9077719 | 0.71 | CNR2 (0.43) | L3MBTL1RXRARXRBRXRGFFAR1 | |
| Propionic Acid SCHEMBL10593320 | 0.69 | POLB (0.64) | POLBSMN1; SMN2TSHRL3MBTL1MAPK1 | |
| SCHEMBL9079405 | 0.67 | AOC3 (0.47) | POLBSMN1; SMN2TSHRL3MBTL1MAPK1 | |
| SCHEMBL22231402 | 0.67 | SMN1; SMN2 (0.41) | POLBSMN1; SMN2TSHRL3MBTL1MAPK1 | |
| SCHEMBL22231401 | 0.67 | SMN1; SMN2 (0.41) | POLBSMN1; SMN2TSHRL3MBTL1MAPK1 | |
| Tetrazole SCHEMBL31454722 | 0.67 | GAA (0.49) | SMN1; SMN2TSHRMAPK1RXRARXRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5508437-A | APPETITE SUPPRESSANTS | HOFFMANN-LA ROCHE INC. (US) | 1996-04-16 | — | — | US | disclosed |
| US-5296608-A | Intermediates for analogs of tyrosine sulfate or tyrosine phosphate containing peptides | HOFFMAN-LA ROCHE INC. (US) | 1994-03-22 | — | — | US | disclosed |
| US-5182263-A | Appetite suppressants | HOFFMANN-LA ROCHE INC. (US) | 1993-01-26 | — | — | US | disclosed |
| EP-0339549-A2 | Tyr-peptide analogs | F. HOFFMANN-LA ROCHE AG (CH) | 1989-11-02 | — | — | EP | disclosed |