Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTB4R | Q15722 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | TBXAS1 | P24557 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.43 |
| ▸ | MMP12 | P39900 | 1/20 | 0.42 |
| ▸ | MMP13 | P45452 | 1/20 | 0.42 |
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.42 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.42 |
| ▸ | HRH1 | P35367 | 2/20 | 0.42 |
| ▸ | BLM | P54132 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27514701 | 0.93 | LTB4R (0.53) | LTB4RLMNAMAPTMAPK1TBXAS1 | |
| SCHEMBL27498072 | 0.89 | TSHR (0.49) | LMNAMAPTMAPK1TBXAS1ALDH1A1 | |
| SCHEMBL8826605 | 0.84 | LTB4R (0.59) | LTB4RLMNAMAPTMAPK1ALDH1A1 | |
| SCHEMBL3254192 | 0.84 | LTB4R (0.59) | LTB4RLMNAMAPTMAPK1ALDH1A1 | |
| SCHEMBL15587062 | 0.84 | LTB4R (0.59) | LTB4RLMNAMAPTMAPK1ALDH1A1 | |
| SCHEMBL10398649 | 0.81 | TBXAS1 (0.59) | LMNATBXAS1 | |
| SCHEMBL10398650 | 0.81 | TBXAS1 (0.59) | LMNATBXAS1 | |
| SCHEMBL13870218 | 0.81 | LTB4R (0.48) | LTB4RALDH1A1CYP3A4BLM | |
| SCHEMBL31745134 | 0.81 | ESR1 (0.47) | LTB4RLMNATBXAS1ALDH1A1CYP3A4 | |
| SCHEMBL14558125 | 0.79 | PTGS1 (0.54) | LTB4RLMNABLM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5569665-A | Peptidyl derivatives and their use as metalloproteinases inhibitors | CELLTECH LIMITED (GB) | 1996-10-29 | — | — | US | disclosed |
| EP-0605682-A1 | PEPTIDYL DERIVATIVES AND THEIR USE AS METALLOPROTEINASES INHIBITORS | CELLTECH THERAPEUTICS LIMITED (GB) | 1994-07-13 | — | — | EP | disclosed |
| WO-1993024449-A1 | PEPTIDYL DERIVATIVES AND THEIR USE AS METALLOPROTEINASES INHIBITORS | CELLTECH LIMITED (GB) | 1993-12-09 | — | — | WO | disclosed |