Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.63 |
| ▸ | GAA | P10253 | 2/20 | 0.60 |
| ▸ | TP53 | P04637 | 1/20 | 0.59 |
| ▸ | MEN1 | O00255 | 5/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | PKM | P14618 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | HPGD | P15428 | 2/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.55 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.55 |
| ▸ | GFER | P55789 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9081167 | 0.92 | ALDH1A1 (0.62) | KDM4EALDH1A1GAAMEN1KMT2A | |
| SCHEMBL22022912 | 0.85 | ALDH1A1 (0.57) | KDM4EALDH1A1GAAMEN1KMT2A | |
| SCHEMBL2271181 | 0.81 | GAA (0.60) | KDM4EALDH1A1GAAMEN1KMT2A | |
| SCHEMBL5696409 | 0.81 | ALDH1A1 (0.63) | KDM4EALDH1A1GAAMEN1KMT2A | |
| SCHEMBL9082681 | 0.81 | MEN1 (0.57) | KDM4EALDH1A1GAAMEN1KMT2A | |
| SCHEMBL22022887 | 0.80 | MEN1 (0.76) | KDM4EALDH1A1GAAMEN1KMT2A | |
| SCHEMBL9080159 | 0.78 | ALDH1A1 (0.61) | KDM4EALDH1A1GAAMEN1KMT2A | |
| SCHEMBL19140453 | 0.77 | ALDH1A1 (0.55) | KDM4EALDH1A1GAAMEN1KMT2A | |
| SCHEMBL1732832 | 0.77 | KDM4E (0.62) | KDM4EALDH1A1GAAMEN1KMT2A | |
| SCHEMBL28618230 | 0.77 | CHEK1 (0.63) | KDM4EALDH1A1GAATP53MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1996034851-A1 | BENZENE, PYRIDINE, NAPHTALENE OR BENZOPHENONE DERIVATIVES AS INHIBITORS OF SQUALENE SYNTHETASE AND PROTEIN FARNESYLTRANSFERASE | ABBOTT LABORATORIES (US) | 1996-11-07 | — | — | WO | disclosed |