Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR1 | O14842 | 6/20 | 0.53 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.52 |
| ▸ | LCK | P06239 | 2/20 | 0.50 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.49 |
| ▸ | EGFR | P00533 | 1/20 | 0.47 |
| ▸ | CDC25B | P30305 | 2/20 | 0.46 |
| ▸ | PTPRB | P23467 | 1/20 | 0.46 |
| ▸ | CDC25A | P30304 | 1/20 | 0.46 |
| ▸ | PTEN | P60484 | 1/20 | 0.46 |
| ▸ | PTPMT1 | Q8WUK0 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.46 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.46 |
| ▸ | CTSB | P07858 | 1/20 | 0.46 |
| ▸ | MMP9 | P14780 | 1/20 | 0.46 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.46 |
| ▸ | DNMT3B | Q9UBC3 | 1/20 | 0.46 |
| ▸ | DNMT3L | Q9UJW3 | 1/20 | 0.46 |
| ▸ | DNMT3A | Q9Y6K1 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23103 | 0.87 | LCK (0.62) | LCKEGFRCDC25BCDC25AKLKB1 | |
| SCHEMBL29404777 | 0.87 | LCK (0.62) | LCKEGFRCDC25BCDC25AKLKB1 | |
| SCHEMBL28891584 | 0.85 | AKR1C3 (0.53) | FFAR1KEAP1CDC25BCDC25AFFAR4 | |
| SCHEMBL9689519 | 0.85 | LCK (0.71) | FFAR1KEAP1LCKEGFRCDC25B | |
| SCHEMBL254346 | 0.83 | KAT8 (0.54) | LCKEGFRCDC25BCDC25AKLKB1 | |
| SCHEMBL16899346 | 0.83 | FFAR4 (0.54) | FFAR1KEAP1P4HTMFFAR4 | |
| SCHEMBL8827540 | 0.83 | ALDH1A1 (0.49) | FFAR1KEAP1LCKP4HTMCDC25B | |
| SCHEMBL11440235 | 0.83 | ALDH1A1 (0.68) | FFAR1KEAP1LCKP4HTMEGFR | |
| SCHEMBL23248603 | 0.82 | SORT1 (0.55) | LCKEGFRCDC25BKLKB1CTSB | |
| SCHEMBL2687820 | 0.82 | KAT8 (0.62) | LCKEGFRCDC25BKLKB1CTSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1996034851-A1 | BENZENE, PYRIDINE, NAPHTALENE OR BENZOPHENONE DERIVATIVES AS INHIBITORS OF SQUALENE SYNTHETASE AND PROTEIN FARNESYLTRANSFERASE | ABBOTT LABORATORIES (US) | 1996-11-07 | — | — | WO | disclosed |